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Free radicals and inflammation: superoxide-dependent activation of a neutrophil chemotactic factor in plasma.
Open accessAbstract
The intravenous administration of superoxide dismutase (superoxide:superoxide oxidoreductase, EC 1.15.1.1) to animals with induced inflammation suppresses the inflammatory response and inhibits leukocyte infiltration into the challenged site, suggesting that neutrophil-generated superoxide reacts with an extracellular precursor to generate a substance chemotactic for neutrophils. Plasma exposed to superoxide in vitro becomes potently chemotactic. The appearance of chemotactic activity is inhibited by superoxide dismutase but not by catalase. The chemotactic factor does not stimulate superoxide production or degranulation in neurtrophils. Intradermal injection of superoxide-treated plasma or of a superoxide-generating system causes heavy infiltration of neutrophils to the injection site but does not cause overt signs of inflammation. The chemotactic factor consists of a chloroform-extractable component bound to serum albumin. The superoxide-dependent chemotactic factor appears to play a major role in communication in neutrophil-mediated inflammatory events. Prevention of production of this factor appears to be the major anti-inflammatory action of superoxide dismutase.
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Citations
Cited by
Superoxide radical and superoxide dismutases
Fridovich, I. (1995) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.64.070195.000525 · Cited by 3,455
Free Radicals as Mediators of Tissue Injury and Disease
Kehrer, J. P. (1993) · Critical Reviews in Toxicology · doi:10.3109/10408449309104073 · Cited by 1,455
Superoxide radicals in feline intestinal ischemia
Granger, D. N., Rutili, G., & McCord, J. M. (1981) · Gastroenterology · doi:10.1016/0016-5085(81)90648-x · Cited by 1,198
Self-citationOxidative stress in health and disease: The therapeutic potential of Nrf2 activation
Hybertson, B. M., Gao, B., Bose, S. K., & McCord, J. M. (2011) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2011.10.006 · Cited by 1,015
Self-citationFridovich, I. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)83102-7 · Cited by 964
Metadata
- Authors
- Petrone, W. F., English, D. K., Wong, K., & McCord, J. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1980-02
- Volume
- 77
- Issue
- 2
- Pages
- 1159-1163
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1982167041
- Cited by
- 616
- References
- 0
- FWCI
- 9.47
- Type
- journal article
- Language
- en
- Open access
- green
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- Petrone, W. F., English, D. K., Wong, K., & McCord, J. M. (1980). Free radicals and inflammation: superoxide-dependent activation of a neutrophil chemotactic factor in plasma. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.77.2.1159
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