The DOI matches its Crossref record; 131 of the 131 references it cites were found in a registry or an index.
Free Radicals as Mediators of Tissue Injury and Disease
Abstract
A radical is any molecule that contains one or more unpaired electrons. Radicals are normally generated in many metabolic pathways. Some of these radicals can exist in a free form and subsequently interact with various tissue components resulting in dysfunction. The potential role of oxygen- or xenobiotic-derived free radicals in the pathology of several human diseases has stimulated extensive research linking the toxicity of numerous xenobiotics and disease processes to a free radical mechanism. However, because free radical-mediated changes are pervasive and often poorly understood, the question of whether such species are a major cause of tissue injury and human disease remains equivocal. This review discusses cellular sources of various radical species and their reactions with vital cellular constituents. Examples of purported free radical-mediated disorders are discussed in detail to provide insights into the controversy over whether free radicals are important mediators of tissue injury.
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Cites
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Book ReviewAmbulatory Pediatric Care
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Cited by
Ischemic Cell Death in Brain Neurons
Lipton, P. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.4.1431 · Cited by 3,043
Role of oxygen radicals in DNA damage and cancer incidence
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Dietary polyphenols and their biological significance
Han, X., Shen, T., & Lou, H. (2007) · International Journal of Molecular Sciences · doi:10.3390/i8090950 · Cited by 1,081
“Oxidative stress is considered to play a pivotal role in the pathogenesis of aging and several degenerative diseases, such as atherosclerosis, cardiovascular disease, type II diabetes and cancer [1-3].”
BackgroundRole of oxidative stress in Alzheimer’s disease
HUANG, W.-J., ZHANG, X., & CHEN, W.-W. (2016) · Biomedical Reports · doi:10.3892/br.2016.630 · Cited by 1,023
Metadata
- Authors
- Kehrer, J. P.
- Venue
- Critical Reviews in Toxicology
- Publisher
- Informa UK Limited
- Published
- 1993-01
- Volume
- 23
- Issue
- 1
- Pages
- 21-48
- ISSN
- 0045-6446 (ISSN-L)
- 1040-8444
- 1547-6898
- OpenAlex
- W2072727557
- Cited by
- 1,455
- References
- 131
- FWCI
- 11.24
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
