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Selective oxidation of cysteine and methionine in normal and senile cataractous lenses.
Open accessAbstract
The oxidation state of methionine and cysteine in normal and cataractous lenses is reported. In young lenses no oxidation was detected in any protein fraction examined. Only the intrinsic membrane fraction and membrane-related components showed evidence of oxidation in old (60-65 years of age) normal lenses. However, in a similar age group, with the development of cataract, progressive, dramatic changes were observed. With severe cataracts, 60% or more of the methionine in membrane-associated components was found in the methionine sulfoxide form, and methionine sulfone was observed in one case. Most of the cysteine was found oxidized to either the disulfide form or putative cysteic acid. Mixed disulfides with glutathione were observed. Oxidative changes in soluble components as illustrated by alpha-crystallin occurred more gradually. The data clearly support the viewpoint that extensive oxidation of lens proteins occurs with cataract and that it begins at the lens fiber membrane.
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Cited by
Oxidants, antioxidants, and the degenerative diseases of aging.
Ames, B. N., Shigenaga, M. K., & Hagen, T. M. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.17.7915 · Cited by 5,958
The oxidative environment and protein damage
Davies, M. J. (2005) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2004.08.007 · Cited by 1,392
Oxidation of methionyl residues in proteins: Tools, targets, and reversal
Vogt, W. (1995) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(94)00158-g · Cited by 883
Molecular and Cellular Aspects of Thiol–Disulfide Exchange
Gilbert, H. F. (1990) · Advances in Enzymology - and Related Areas of Molecular Biology · doi:10.1002/9780470123096.ch2 · Cited by 758
Hydrogen peroxide and human cataract
Spector, A., & Garner, W. H. (1981) · Experimental Eye Research · doi:10.1016/s0014-4835(81)80107-8 · Cited by 502
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Metadata
- Authors
- Garner, M. H., & Spector, A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1980-03
- Volume
- 77
- Issue
- 3
- Pages
- 1274-1277
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1975980571
- Cited by
- 298
- References
- 0
- FWCI
- 3.83
- Type
- journal article
- Language
- en
- Open access
- green
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- Garner, M. H., & Spector, A. (1980). Selective oxidation of cysteine and methionine in normal and senile cataractous lenses. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.77.3.1274
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