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A mechanism for RNA splicing.
Open accessAbstract
The most abundant of the stable small nuclear RNAs of eukaryotic cells, U-1 small nuclear RNA, is exactly complementary to the consensus sequences at RNA splice sites. We propose that this RNA is the recognition component of the nuclear RNA splicing enzyme and forms base pairs with both ends of an intron so as to align them for cutting and splicing.
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Cited by
The U1 small nuclear RNA-protein complex selectively binds a 5′ splice site in vitro
Mount, S. M., Pettersson, I., Hinterberger, M., Karmas, A., & Steitz, J. A. (1983) · Cell · doi:10.1016/0092-8674(83)90432-4 · Cited by 565
Izant, J. G., & Weintraub, H. (1984) · Cell · doi:10.1016/0092-8674(84)90050-3 · Cited by 549
Krainer, A. R., & Maniatis, T. (1985) · Cell · doi:10.1016/0092-8674(85)90269-7 · Cited by 419
Before enzymes and templates: theory of surface metabolism
Wächtershäuser, G. (1988) · Microbiological Reviews · doi:10.1128/mmbr.52.4.452-484.1988 · Cited by 1,242
Structure of spliceosomal snRNPs and their role in pre-mRNA splicing
Lührmann, R., Kastner, B., & Bach, M. (1990) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/0167-4781(90)90001-i · Cited by 403
Metadata
- Authors
- Rogers, J., & Wall, R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1980-04
- Volume
- 77
- Issue
- 4
- Pages
- 1877-1879
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2073105366
- Cited by
- 539
- References
- 0
- FWCI
- 33.63
- Type
- journal article
- Language
- en
- Open access
- green
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- Rogers, J., & Wall, R. (1980). A mechanism for RNA splicing. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.77.4.1877
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
