The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Permissive effect of the extracellular matrix on cell proliferation in vitro.
Open accessAbstract
Corneal endothelial cells maintained in tissue culture retain the ability to synthesize and secrete an extracellular matrix (ECM) along their basal cell surface. Treatment of confluent cultures with 0.5% Triton X-100 results in the removal of the cell monolayer, thereby exposing the ECM, which adheres strongly to the tissue culture dish. Dishes coated with ECM were used to study the permissive effect of such a substrate on cell proliferation. The proliferation of bovine granulosa and adrenal cortex cells maintained on plastic tissue culture dishes was compared to that on dishes coated with ECM. Neither cell type, even when exposed to optimal serum concentration, replicated when seeded at low cell density on plastic. In contrast, when seeded on ECM they proliferated actively. None of the cultures maintained on ECM required fibroblast growth factor in order to reach confluence, although when maintained on plastic they were totally dependent on fibroblast growth factor for proliferation. Because cells maintained on plastic do not respond to factors present in serum or plasma, although they do so respond when maintained on ECM, it is likely that the close contact of the cells with the ECM restores their sensitivity to agents present in serum and plasma.
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Cites
Role of cell shape in growth control
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Binding of soluble form of fibroblast surface protein, fibronectin, to collagen
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Distribution of a major connective tissue protein, fibronectin, in normal human tissues.
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Gospodarowicz, D., Greenburg, G., & Birdwell, C. R. (1978) · PubMed · Cited by 491
Self-citationThe Growth of Cells on a Transparent Gel of Reconstituted Rat-Tail Collagen 2
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Gospodarowicz, D., Mescher, A. L., & Birdwell, C. R. (1977) · Experimental Eye Research · doi:10.1016/0014-4835(77)90248-2 · Cited by 337
Self-citationVLODAVSKY, I., LUI, G., & GOSPODAROWICZ, D. (1980) · Cell · doi:10.1016/s0092-8674(80)80037-7 · Cited by 309
Self-citationYang, J., Richards, J., Bowman, P., Guzman, R., Enami, J., McCormick, K., Hamamoto, S., Pitelka, D., & Nandi, S. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.7.3401 · Cited by 284
Extracellular Matrix and Control of Proliferation of Vascular Endothelial Cells
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Cited by
Chiquet-Ehrismann, R., Mackie, E. J., Pearson, C. A., & Sakakura, T. (1986) · Cell · doi:10.1016/0092-8674(86)90374-0 · Cited by 992
Ishimoto, H., & Jaffe, R. B. (2011) · Endocrine Reviews · doi:10.1210/er.2010-0001 · Cited by 379
Wang, Y., Cui, C.-B., Yamauchi, M., Miguez, P., Roach, M., Malavarca, R., Costello, J. M., Cardinale, V., Wauthier, E., Barbier, C., et al. (2011) · Hepatology · doi:10.1002/hep.24012 · Cited by 220
Extracellular matrix proteins of human epidermal keratinocytes and feeder 3T3 cells.
Alitalo, K., Kuismanen, E., Myllylä, R., Kiistala, U., Asko-Seljavaara, S., & Vaheri, A. (1982) · The Journal of cell biology · doi:10.1083/jcb.94.3.497 · Cited by 140
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Metadata
- Authors
- Gospodarowicz, D., Delgado, D., & Vlodavsky, I.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1980-07
- Volume
- 77
- Issue
- 7
- Pages
- 4094-4098
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2078571162
- Cited by
- 417
- References
- 14
- FWCI
- 13.85
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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