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Cited by 331

The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.

Apical membrane aminopeptidase appears at site of cell-cell contact in cultured kidney epithelial cells.

Open access
Louvard, D·1980·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.77.7.4132
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Abstract

A dog kidney epithelial cell line (MDCK), grown in monolayer, displayed in vitro an asymmetric localization of surface proteins. Aminopeptidase [alpha-aminoacylpeptide hydrolase (microsomal), EC 3.4.11.2] was found only in the apical face whereas Na+, K+-ATPase (ATP phosphohydrolase, EC 3.6.1.3) was found in the basolateral faces. These two faces are delineated by the junctional complex at which close cell-cell contact occurs. alpha-Actinin, a protein associated with plasma membranes, was concentrated near the region of cell-cell contact. When membrane proteins in the apical surface were crosslinked and subsequently removed from the surface by endocytosis, crosslinked antigens reappeared in the apical face at the region of cell-cell contact. Antigens that were not crosslinked were also (re)inserted in the same region. This process was not affected by cycloheximide, presumably because a large pool of apical membrane proteins (observed in small cytoplasmic vesicles) was used to replace the endocytosed antigens. It is psoposed that the region containing the junctional complex is involved in guiding apical membrane proteins to their final location.

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Metadata

Authors
Louvard, D.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
1980-07
Volume
77
Issue
7
Pages
4132-4136
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.77.7.4132
OpenAlex
W2164057833
Cited by
331
References
17
FWCI
10.07
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Apical membrane aminopeptidase appears at site of cell-cell contact in cultured kidney epithelial cells. https://app.cochat.ai/papers/10.1073/pnas.77.7.4132
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Louvard, D. (1980). Apical membrane aminopeptidase appears at site of cell-cell contact in cultured kidney epithelial cells. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.77.7.4132

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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