The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Adenosine receptors in brain membranes: binding of N6-cyclohexyl[3H]adenosine and 1,3-diethyl-8-[3H]phenylxanthine.
Open accessAbstract
N6-Cyclohexyl[3H]adenosine ([3H]CHA) and 1,3-diethyl-8-[3H]phenylxanthine ([3H]DPX) to bind to adenosine receptors in brain membranes. The agonist [3H]CHA has high affinity in both bovine and guinea pig brain (Kd, 0.7 nM and 6 nM, respectively). [3H]CHA binding kinetics are slow (dissociation t1/2;60 min); binding is much higher at 25 degrees C than at 0 degrees C and is inhibited by guanine nucleotides. Potencies of nucleosides and xanthines in competing for [3H]CHA sites indicate that specific binding is entirely to A1 adenosine receptors. In bovine brain, the antagonist [3H]DPX exhibits high-affinity binding (Kd, 5 nM) to the same A1 receptors that bind [3H]CHA. Binding kinetics are rapid (dissociation t1/2, 1 min), and binding is moderately higher at 0 degrees C than at 25 degrees C. In guinea pig brain, [3H]DPX binding has only moderate affintiy (Kd 50 nM), and about 60% of specific binding is to sites that resemble A2 adenosine receptors.
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Cites
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Rodbell, M. (1980) · Nature · doi:10.1038/284017a0 · Cited by 1,749
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Two distinct adenosine-sensitive sites on adenylate cyclase.
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Adenosine receptor activation in human fibroblasts: nucleoside agonists and antagonists
Bruns, R. F. (1980) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y80-110 · Cited by 196
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Cited by
International Union of Pharmacology. XXV. Nomenclature and Classification of Adenosine Receptors
Fredholm, B. B., IJzerman, A. P., Jacobson, K. A., Klotz, K.-N., & Linden, J. (2001) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01511-4 · Cited by 2,585
The Physiological Role of Adenosine In The Central Nervous System
Dunwiddie, T. V. (1985) · International Review of Neurobiology · doi:10.1016/s0074-7742(08)60556-5 · Cited by 623
Kobie, J. J., Shah, P. R., Yang, L., Rebhahn, J. A., Fowell, D. J., & Mosmann, T. R. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.10.6780 · Cited by 466
Adenosine Inhibition of Mesopontine Cholinergic Neurons: Implications for EEG Arousal
Rainnie, D. G., Grunze, H. C. R., McCarley, R. W., & Greene, R. W. (1994) · Science · doi:10.1126/science.8303279 · Cited by 340
The Health Consequences of Caffeine
CURATOLO, P. W., & ROBERTSON, D. (1983) · Annals of Internal Medicine · doi:10.7326/0003-4819-98-5-641 · Cited by 271
Metadata
- Authors
- Bruns, R. F., Daly, J. W., & Snyder, S. H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1980-09
- Volume
- 77
- Issue
- 9
- Pages
- 5547-5551
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1983223101
- Cited by
- 548
- References
- 8
- FWCI
- 19.50
- Type
- journal article
- Language
- en
- Open access
- green
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- Bruns, R. F., Daly, J. W., & Snyder, S. H. (1980). Adenosine receptors in brain membranes: binding of N6-cyclohexyl[3H]adenosine and 1,3-diethyl-8-[3H]phenylxanthine. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.77.9.5547
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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