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ADENOSINE REGULATES VIA TWO DIFFERENT TYPES OF RECEPTORS, THE ACCUMULATION OF CYCLIC AMP IN CULTURED BRAIN CELLS
Abstract
Abstract— In cell cultures of glial character derived from perinatal mouse brain adenosine elicits two effects. (a) At submicromolar concentrations It inhibits the increase in the intracellular level of cyclic AMP caused by β‐adrenoceptor agonists. (b) At concentrations above micromolar it increases the level of cyclic AMP in the cultures. These two effects are mediated by two different adenosine receptors present on the outer surface of the cells. This is concluded from the following evidence. (a) Both effects are antagonized by methylxanthines but not by blockage of adenosine uptake or inhibition of phosphodiesterase activity. (b) In both cases activity depends on the integrity of the ribose moiety of the nucleotide. Substituents of the purine system are tolerated comparatively well. (c) The order of potency of adenosine analogues is different for the two effects. We suggest the name A1 receptors for those that mediate the inhibition and A2 for those that mediate the stimulation of cyclic AMP accumulation.
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Citations
Cited by
International Union of Pharmacology. XXV. Nomenclature and Classification of Adenosine Receptors
Fredholm, B. B., IJzerman, A. P., Jacobson, K. A., Klotz, K.-N., & Linden, J. (2001) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01511-4 · Cited by 2,585
Nomenclature and classification of purinoceptors.
Fredholm, B. B., Abbracchio, M. P., Burnstock, G., Daly, J. W., Harden, T. K., Jacobson, K. A., Leff, P., & Williams, M. (1994) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06782-1 · Cited by 1,585
Adenosine Receptors as Therapeutic Targets
Jacobson, K. A., & Gao, Z.-G. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd1983 · Cited by 1,431
McCormick, D. A. (1992) · Progress in Neurobiology · doi:10.1016/0301-0082(92)90012-4 · Cited by 1,117
Mediero, A., & Cronstein, B. N. (2013) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2013.02.001 · Cited by 133
Metadata
- Authors
- Calker, D. V., Müller, M., & Hamprecht, B.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 1979-11
- Volume
- 33
- Issue
- 5
- Pages
- 999-1005
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W2001110103
- Cited by
- 1,371
- References
- 0
- FWCI
- 13.05
- Type
- journal article
- Language
- en
- Open access
- closed
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- Calker, D. V., Müller, M., & Hamprecht, B. (1979). ADENOSINE REGULATES VIA TWO DIFFERENT TYPES OF RECEPTORS, THE ACCUMULATION OF CYCLIC AMP IN CULTURED BRAIN CELLS. Journal of Neurochemistry. https://doi.org/10.1111/j.1471-4159.1979.tb05236.x
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