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The persisting (P) cell: histamine content, regulation by a T cell‐derived factor, origin from a bone marrow precursor, and relationship to mast cells
Abstract
Histamine was detected at levels of 100 ng/10(6) cells in the metachromatic granules of the persisting (P) cell, which appears in cultures of murine lymphoid or bone marrow cells and is capable of long-term growth in vitro in the presence of a T cell-derived growth factor. This factor, which we termed P-cell stimulating factor, was distinct from t-cell growth factor and had an apparent molecular weight of 25,000-30,000. P cells did not originate from Thy.1-positive cells nor was the thymus necessary for the development of their precursors. Moreover, P cells grew directly from colonies generated in agar cultures of bone marrow cells, the nature of the colonies indicating that P cells shared a common precursor with hemopoietic cells. Mutant Wf/Wf mice, although deficient in certain mast cells, possessed P-cell precursors. It is hypothesized that P cells are related to a specialized subset of mast cells, derived from a bone marrow progenitor but regulated by activated T cells.
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“These findings were the first indication that mast cells are indeed hematopoietic in nature.”
From Mast cell ontogeny: From fetal development to life‐long health and disease (2023) · cites this paper as [25]
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Research works printed but not linked: 7
- [9]Schrader, J. W., Clark-Lewis, I. & Bartlett, P. (1980) in ICNUCLA Symposia on Molecular and Cellular Biology, eds. Gale, R. P. & Fox, C. F. (Academic, New York), Vol. 17, pp. 443–459.
- [24]Metcalf, D. & Moore, M. A. S. (1971) Hemopoietic Cells (NorthHolland, Amsterdam), pp. 493–495.
- [25]Kahlson, G. & Rosengren, E. (1971) Biogenesis and Physiology of Histamine (Arnold, London), pp. 217–251.
- [27]Byron, J. W. (1978) in Differentiation of Normal and Neoplastic Hematopoietic Cells, eds. Clarkson, B., Marks, P. A. & Till, J. E. (Cold Spring Harbor Laboratory, Cold Spring Harbor, NY), pp. 121-130.
- [30]Metcalf, D. (1979) in Biology of the Lymphokines, eds. Cohen, S., Pick, E. .& Oppenheim, J. (Academic, New York), pp. 515-540.
- [32]Schrader, J. W. (1981) J. Immunol. 126, in press.
- [31]Stanley, E. R. (1979) Proc. Natl. Acad. Sci. USA 76, 2969–2973.
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Metzler, M., Gertz, A., Sarkar, M., Schachter, H., Schrader, J. W., & Marth, J. D. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06480.x · Cited by 339
Self-citationMast cell ontogeny: From fetal development to life‐long health and disease
Chia, S. L., Kapoor, S., Carvalho, C., Bajénoff, M., & Gentek, R. (2023) · Immunological Reviews · doi:10.1111/imr.13191 · Cited by 60
Metadata
- Authors
- Schrader, J. W., Lewis, S. J., Clark-Lewis, I., & Culvenor, J. G.
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1981-01
- Volume
- 78
- Issue
- 1
- Pages
- 323-327
- ISSN
- 0027-8424
- 1091-6490
- Cited by
- 139
- References
- 0
- Language
- en
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- CoChat. (2026). Citation check: The persisting (P) cell: histamine content, regulation by a T cell‐derived factor, origin from a bone marrow precursor, and relationship to mast cells. https://app.cochat.ai/papers/10.1073/pnas.78.1.323
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- Schrader, J. W., Lewis, S. J., Clark-Lewis, I., & Culvenor, J. G. (1981). The persisting (P) cell: histamine content, regulation by a T cell‐derived factor, origin from a bone marrow precursor, and relationship to mast cells. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.78.1.323
