The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Interactions among clonal subpopulations affect stability of the metastatic phenotype in polyclonal populations of B16 melanoma cells.
Open accessAbstract
Analysis of the metastatic properties of clones isolated from mouse B16 melanoma cell lines (B16-F1 and F10) shows extensive cellular heterogeneity and the presence of subpopulations that have widely differing metastatic abilities. This pattern of metastatic heterogeneity is maintained during serial passage in vitro and in vivo. In contrast, even a short serial passage of individual clones isolated from these heterogeneous parent lines results in rapid emergence of variant subclones that have different metastatic properties. If several clones are mixed and cocultivated, this instability is not expressed. These data suggest that, in polyclonal populations, the various clonal subpopulations somehow interact with one another to "stabilize" their relative proportions within the population. Restriction of clonal diversity by selective killing of the majority of clones in a polyclonal population eliminates the stabilizing restraints and stimulates rapid emergence of new subpopulations to create heterogeneous populations containing a new panel of phenotypically diverse subpopulations that then reach stable proportions until the next selection pressure(s) is encountered.
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Cites
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Self-citationIn vitro selection of murine B16 melanoma variants with enhanced tissue-invasive properties.
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Self-citationGROWTH OF A LOCAL TUMOR EXERTS A SPECIFIC INHIBITORY EFFECT ON PROGRESSION OF LUNG METASTASES
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Cited by
Biological Diversity in Metastatic Neoplasms: Origins and Implications
Fidler, I. J., & Hart, I. R. (1982) · Science · doi:10.1126/science.7112116 · Cited by 928
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Type IV collagenases in tumor invasion and metastasis
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Antisense RNA-Induced Reduction in Murine TIMP Levels Confers Oncogenicity on Swiss 3T3 Cells
Khokha, R., Waterhouse, P., Yagel, S., Lala, P. K., Overall, C. M., Norton, G., & Denhardt, D. T. (1989) · Science · doi:10.1126/science.2465572 · Cited by 451
Metadata
- Authors
- Poste, G., Doll, J., & Fidler, I. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1981-10
- Volume
- 78
- Issue
- 10
- Pages
- 6226-6230
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2041002260
- Cited by
- 301
- References
- 12
- FWCI
- 16.77
- Type
- journal article
- Language
- en
- Open access
- green
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- Poste, G., Doll, J., & Fidler, I. J. (1981). Interactions among clonal subpopulations affect stability of the metastatic phenotype in polyclonal populations of B16 melanoma cells. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.78.10.6226
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
