The DOI matches its Crossref record.
Antisense RNA-Induced Reduction in Murine TIMP Levels Confers Oncogenicity on Swiss 3T3 Cells
Abstract
Mouse 3T3 cell lines capable of constitutively synthesizing an RNA complementary to the messenger RNA encoding TIMP, tissue inhibitor of metalloproteinases, were constructed by transfection with appropriate plasmid constructs. Many of the lines were down-modulated for TIMP messenger RNA levels and secreted less TIMP into the culture medium. In comparison to noninvasive, nontumorigenic controls, these cells not only were invasive in a human amnion invasion assay, but also were tumorigenic and metastatic in athymic mice. These results indicate that TIMP suppresses oncogenicity, at least in immortal murine 3T3 cells.
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Cited by
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Sternlicht, M. D., & Werb, Z. (2001) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.17.1.463 · Cited by 3,959
Matrix Metalloproteinase Inhibitors and Cancer—Trials and Tribulations
Coussens, L. M., Fingleton, B., & Matrisian, L. M. (2002) · Science · doi:10.1126/science.1067100 · Cited by 2,761
Strategies for MMP inhibition in cancer: innovations for the post-trial era
Overall, C. M., & López-Otín, C. (2002) · Nature Reviews Cancer · doi:10.1038/nrc884 · Cited by 1,349
Self-citationGoldberg, G. I., Marmer, B. L., Grant, G. A., Eisen, A. Z., Wilhelm, S., & He, C. S. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.21.8207 · Cited by 586
Differentially expressed protein Pdcd4 inhibits tumor promoter-induced neoplastic transformation
Cmarik, J. L., Min, H., Hegamyer, G., Zhan, S., Kulesz-Martin, M., Yoshinaga, H., Matsuhashi, S., & Colburn, N. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.24.14037 · Cited by 254
Metadata
- Authors
- Khokha, R., Waterhouse, P., Yagel, S., Lala, P. K., Overall, C. M., Norton, G., & Denhardt, D. T.
- Venue
- Science
- Published
- 1989-02-17
- Volume
- 243
- Issue
- 4893
- Pages
- 947-950
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2077483002
- Cited by
- 451
- References
- 0
- FWCI
- 21.36
- Type
- journal article
- Language
- en
- Open access
- closed
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- Khokha, R., Waterhouse, P., Yagel, S., Lala, P. K., Overall, C. M., Norton, G., & Denhardt, D. T. (1989). Antisense RNA-Induced Reduction in Murine TIMP Levels Confers Oncogenicity on Swiss 3T3 Cells. Science. https://doi.org/10.1126/science.2465572
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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