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Are the presynaptic membrane particles the calcium channels?
Open accessAbstract
The number of large intramembrane particles associated with sites of synaptic vesicle release at the squid giant synapse was determined and compared to the average maximal presynaptic calcium current in order to derive an estimate of the conductance each particle would have if it were a calcium channel. This value, 0.21 pS, compares favorably with conductances of calcium channels in other preparations, substantiating the idea that the large intramembrane particles, which are concentrated at "active zones," represent calcium channels.
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Citations
Cited by
Neher, E. (1998) · Neuron · doi:10.1016/s0896-6273(00)80983-6 · Cited by 1,010
Nanodomain coupling between Ca2+ channels and sensors of exocytosis at fast mammalian synapses
Eggermann, E., Bucurenciu, I., Goswami, S. P., & Jonas, P. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3125 · Cited by 500
Calcium requirements for secretion in bovine chromaffin cells.
Augustine, G. J., & Neher, E. (1992) · The Journal of Physiology · doi:10.1113/jphysiol.1992.sp019126 · Cited by 414
Structure and function of neuronal Ca2+ channels and their role in neurotransmitter release
Catterall, W. A. (1998) · Cell Calcium · doi:10.1016/s0143-4160(98)90055-0 · Cited by 386
A Spatial-Temporal Model of Cell Activation
Alkon, D. L., & Rasmussen, H. (1988) · Science · doi:10.1126/science.2830669 · Cited by 342
Metadata
- Authors
- Pumplin, D. W., Reese, T. S., & Llinás, R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1981-11
- Volume
- 78
- Issue
- 11
- Pages
- 7210-7213
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2093441174
- Cited by
- 316
- References
- 0
- FWCI
- 4.23
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Are the presynaptic membrane particles the calcium channels? https://app.cochat.ai/papers/10.1073/pnas.78.11.7210
- The paper
- Pumplin, D. W., Reese, T. S., & Llinás, R. (1981). Are the presynaptic membrane particles the calcium channels? Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.78.11.7210
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
