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Complete amino acid sequence of bovine thymosin beta 4: a thymic hormone that induces terminal deoxynucleotidyl transferase activity in thymocyte populations.
Open accessAbstract
The amino acid sequence of thymosin beta 4, a polypeptide isolated from calf thymus, was determined. Thymosin beta 4 is composed of 43 amino acid residues and has a molecular weight of 4982 and an isoelectric point of 5.1. The NH2 terminus of the peptide is blocked by an acetyl group. This molecule induces expression of terminal deoxynucleotidyl transferase (DNA nucleotidylexotransferase, EC 2.7.7.31) in transferase-negative murine thymocytes in vivo and in citro. Thus, it appears that thymosin beta 4 acts on lymphoid stem cells and may control the early stages of the maturation process of thymus-dependent lymphocytes. This peptide is one of several present in thymosin fraction 5 that participates in the regulation, differentiation, and function of thymus-dependent thymocytes.
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Citations
Cited by
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Ljubimov, A. V., & Saghizadeh, M. (2015) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2015.07.002 · Cited by 872
β-Thymosins, small acidic peptides with multiple functions
Huff, T., Müller, C. S. G., Otto, A. M., Netzker, R., & Hannappel, E. (2001) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(00)00087-x · Cited by 377
Thymosin β4 Accelerates Wound Healing
Malinda, K. M., Kleinman, H. K., Sidhu, G. S., Mani, H., Banaudha, K., Maheshwari, R. K., & Goldstein, A. L. (1999) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.1999.00708.x · Cited by 274
Self-citationThymosin β: actin-sequestering protein moonlights to repair injured tissues
GOLDSTEIN, A., HANNAPPEL, E., & KLEINMAN, H. (2005) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2005.07.004 · Cited by 250
Self-citationSosne, G., Szliter, E. A., Barrett, R., Kernacki, K. A., Kleinman, H., & Hazlett, L. D. (2002) · Experimental Eye Research · doi:10.1006/exer.2001.1125 · Cited by 217
Metadata
- Authors
- Low, T. L., Hu, S. K., & Goldstein, A. L.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1981-02
- Volume
- 78
- Issue
- 2
- Pages
- 1162-1166
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2053779136
- Cited by
- 293
- References
- 0
- FWCI
- 4.60
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Complete amino acid sequence of bovine thymosin beta 4: a thymic hormone that induces terminal deoxynucleotidyl transferase activity in thymocyte populations. https://app.cochat.ai/papers/10.1073/pnas.78.2.1162
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- Low, T. L., Hu, S. K., & Goldstein, A. L. (1981). Complete amino acid sequence of bovine thymosin beta 4: a thymic hormone that induces terminal deoxynucleotidyl transferase activity in thymocyte populations. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.78.2.1162
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