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Interaction of alpha-actinin and vinculin with actin: opposite effects on filament network formation.
Open accessAbstract
The interaction of actin filaments with two actin-associated proteins, alpha-actinin and vinculin (Mr 130,000 protein), was studied in vitro with viscometry and light and electron microscopy. Vinculin, like alpha-actinin, binds to F-actin, and the two proteins were found to have different effects on the formation of filament networks: alpha-actinin crosslinks individual filaments in a manner strongly dependent on temperature and acts as a spacer, whereas vinculin forms actin bundles that display a paracrystalline substructure. In viscometric assays, alpha-actinin mimics the effect of actin gelation factors, whereas vinculin acts as a gelation inhibitor. These findings imply complementary functions of these proteins in the regulation of cellular mobility.
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Cited by
Whitfield, M. L., Sherlock, G., Saldanha, A. J., Murray, J. I., Ball, C. A., Alexander, K. E., Matese, J. C., Perou, C. M., Hurt, M. M., Brown, P. O., et al. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.02-02-0030 · Cited by 1,527
An interaction between vinculin and talin
Burridge, K., & Mangeat, P. (1984) · Nature · doi:10.1038/308744a0 · Cited by 440
A 25-kD inhibitor of actin polymerization is a low molecular mass heat shock protein.
Miron, T., Vancompernolle, K., Vandekerckhove, J., Wilchek, M., & Geiger, B. (1991) · The Journal of cell biology · doi:10.1083/jcb.114.2.255 · Cited by 438
Recruitment of the Arp2/3 complex to vinculin
DeMali, K. A., Barlow, C. A., & Burridge, K. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200206043 · Cited by 425
The structure and function of α-actinin
Blanchard, A., Ohanian, V., & Critchley, D. (1989) · Journal of Muscle Research and Cell Motility · doi:10.1007/bf01758424 · Cited by 425
Metadata
- Authors
- Jockusch, B. M., & Isenberg, G.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1981-05
- Volume
- 78
- Issue
- 5
- Pages
- 3005-3009
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2017504202
- Cited by
- 234
- References
- 0
- FWCI
- 8.15
- Type
- journal article
- Language
- en
- Open access
- green
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- Jockusch, B. M., & Isenberg, G. (1981). Interaction of alpha-actinin and vinculin with actin: opposite effects on filament network formation. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.78.5.3005
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
