The DOI matches its Crossref record; 62 of the 62 references it cites were found in a registry or an index.
Recruitment of the Arp2/3 complex to vinculin
Open accessAbstract
Cell migration involves many steps, including membrane protrusion and the development of new adhesions. Here we have investigated whether there is a link between actin polymerization and integrin engagement. In response to signals that trigger membrane protrusion, the actin-related protein (Arp)2/3 complex transiently binds to vinculin, an integrin-associated protein. The interaction is regulated, requiring phosphatidylinositol-4,5-bisphosphate and Rac1 activation, and is sufficient to recruit the Arp2/3 complex to new sites of integrin aggregation. Binding of the Arp2/3 complex to vinculin is direct and does not depend on the ability of vinculin to associate with actin. We have mapped the binding site for the Arp2/3 complex to the hinge region of vinculin, and a point mutation in this region selectively blocks binding to the Arp2/3 complex. Compared with WT vinculin, expression of this mutant in vinculin-null cells results in diminished lamellipodial protrusion and spreading on fibronectin. The recruitment of the Arp2/3 complex to vinculin may be one mechanism through which actin polymerization and membrane protrusion are coupled to integrin-mediated adhesion.
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Cites
Calcium's Role in Mechanotransduction during Muscle Development
Benavides Damm, T., & Egli, M. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000356667 · Cited by 14,502
Nobes, C. D., & Hall, A. (1995) · Cell · doi:10.1016/0092-8674(95)90370-4 · Cited by 4,412
The small GTP-binding protein rac regulates growth factor-induced membrane ruffling
Ridley, A. J., Paterson, H. F., Johnston, C. L., Diekmann, D., & Hall, A. (1992) · Cell · doi:10.1016/0092-8674(92)90164-8 · Cited by 3,652
Molecular Mechanisms Controlling Actin Filament Dynamics in Nonmuscle Cells
Pollard, T. D., Blanchoin, L., & Mullins, R. D. (2000) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.biophys.29.1.545 · Cited by 1,514
Mullins, R. D., Heuser, J. A., & Pollard, T. D. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.11.6181 · Cited by 1,433
Rohatgi, R., Ma, L., Miki, H., Lopez, M., Kirchhausen, T., Takenawa, T., & Kirschner, M. W. (1999) · Cell · doi:10.1016/s0092-8674(00)80732-1 · Cited by 1,348
Integrin function: molecular hierarchies of cytoskeletal and signaling molecules.
Miyamoto, S., Teramoto, H., Coso, O. A., Gutkind, J. S., Burbelo, P. D., Akiyama, S. K., & Yamada, K. M. (1995) · The Journal of cell biology · doi:10.1083/jcb.131.3.791 · Cited by 1,203
Svitkina, T. M., & Borisy, G. G. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.145.5.1009 · Cited by 1,180
Molecular complexity and dynamics of cell-matrix adhesions
Zamir, E., & Geiger, B. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.20.3583 · Cited by 1,108
Machesky, L. M., & Insall, R. H. (1998) · Current Biology · doi:10.1016/s0960-9822(98)00015-3 · Cited by 918
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Bershadsky, A. D., Balaban, N. Q., & Geiger, B. (2003) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.19.111301.153011 · Cited by 874
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Le Clainche, C., & Carlier, M.-F. (2008) · Physiological Reviews · doi:10.1152/physrev.00021.2007 · Cited by 849
Genetic and cell biological analysis of integrin outside-in signaling
Legate, K. R., Wickström, S. A., & Fässler, R. (2009) · Genes & Development · doi:10.1101/gad.1758709 · Cited by 802
Choi, C. K., Vicente-Manzanares, M., Zareno, J., Whitmore, L. A., Mogilner, A., & Horwitz, A. R. (2008) · Nature Cell Biology · doi:10.1038/ncb1763 · Cited by 797
Metadata
- Authors
- DeMali, K. A., Barlow, C. A., & Burridge, K.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2002-12-09
- Volume
- 159
- Issue
- 5
- Pages
- 881-891
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2099158550
- Cited by
- 425
- References
- 62
- FWCI
- 8.68
- Type
- journal article
- Language
- en
- Open access
- green
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- DeMali, K. A., Barlow, C. A., & Burridge, K. (2002). Recruitment of the Arp2/3 complex to vinculin. The Journal of Cell Biology. https://doi.org/10.1083/jcb.200206043
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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