The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Spontaneous tandem genetic duplications in Salmonella typhimurium arise by unequal recombination between rRNA (rrn) cistrons.
Open accessAbstract
A method is described to detect and measure the frequency of spontaneous tandem genetic duplications located throughout the Salmonella genome. The method is based on the ability of duplication-containing strains to inherit two selectable alleles of a single gene during generalized transductional crosses. One allele of the gene carries an insertion of the translocatable tetracycline-resistance element Tn10; the other allele is a wild-type copy of that gene. Using this technique, we have measured the frequency of tandem duplications at 38 chromosomal sites and the amount of material included in 199 independent duplications. These results suggest that, in one region of the chromosome, tandem duplications are particularly frequent events. Such duplications have end points within rRNA (rrn) cistrons and probably arise by unequal cross-over between these dispersed repeated sequences. Spontaneously duplications of this type are harbored by as much as 3% of the bacterial population. Preliminary evidence suggests that such duplications may play a significant regulatory role under conditions of rapid growth. Our analysis has suggested the position on the genome of an additional rRNA cistron.
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Cites
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Cited by
Slipped-strand mispairing: a major mechanism for DNA sequence evolution.
(1987) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a040442 · Cited by 2,245
Mechanisms and clinical relevance of bacterial heteroresistance
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Evolving responsively: adaptive mutation
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Bergthorsson, U., Andersson, D. I., & Roth, J. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707158104 · Cited by 405
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Metadata
- Authors
- Anderson, P., & Roth, J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1981-05
- Volume
- 78
- Issue
- 5
- Pages
- 3113-3117
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2107738680
- Cited by
- 288
- References
- 12
- FWCI
- 3.77
- Type
- journal article
- Language
- en
- Open access
- green
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- Anderson, P., & Roth, J. (1981). Spontaneous tandem genetic duplications in Salmonella typhimurium arise by unequal recombination between rRNA (rrn) cistrons. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.78.5.3113
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