The DOI matches its Crossref record.
Attachment of smooth muscle cells to collagen and their migration toward platelet-derived growth factor.
Open accessAbstract
Smooth muscle cells use fibronectin to bind to type I and type III collagens but bind to type V collagen by a trypsin-resistant intrinsic glycoconjugate. The binding site on type V collagen is located in the alpha A chain. By using collagen-coated filters in a modified Boyden chamber assay for chemotaxis, it was observed that the platelet-derived growth factor was chemotactic for smooth muscle cells but that several other growth factors were inactive. We suggest that the migration of smooth muscle cells from the media to the intima of a blood vessel, which leads to the formation of an atherosclerotic plaque, may be the result of a chemotactic migration of cells responsive to the platelet-derived growth factor.
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Citations
Cited by
Grotendorst, G. R., Martin, G. R., Pencev, D., Sodek, J., & Harvey, A. K. (1985) · Journal of Clinical Investigation · doi:10.1172/jci112243 · Cited by 275
Self-citationPapakonstantinou, E., Karakiulakis, G., Roth, M., & Block, L. H. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.21.9881 · Cited by 85
Collagen in Dermal Wound Repair
McPherson, J. M., & Piez, K. A. (1988) · The Molecular and Cellular Biology of Wound Repair · doi:10.1007/978-1-4615-1795-5_20 · Cited by 39
Metadata
- Authors
- Grotendorst, G. R., Seppä, H. E., Kleinman, H. K., & Martin, G. R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1981-06
- Volume
- 78
- Issue
- 6
- Pages
- 3669-3672
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2088468623
- Cited by
- 504
- References
- 0
- FWCI
- 16.81
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Attachment of smooth muscle cells to collagen and their migration toward platelet-derived growth factor. https://app.cochat.ai/papers/10.1073/pnas.78.6.3669
- The paper
- Grotendorst, G. R., Seppä, H. E., Kleinman, H. K., & Martin, G. R. (1981). Attachment of smooth muscle cells to collagen and their migration toward platelet-derived growth factor. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.78.6.3669
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
