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On the attribution and additivity of binding energies
Open accessAbstract
It can be useful to describe the Gibbs free energy changes for the binding to a protein of a molecule, A—B, and of its component parts, A and B, in terms of the “intrinsic binding energies” of A and B, Δ G A i and Δ G B i , and a “connection Gibbs energy,” Δ G s that is derived largely from changes in translational and rotational entropy. This empirical approach avoids the difficult or insoluble problem of interpreting observed ΔH and T Δ S values for aqueous solutions. The Δ G i and Δ G s terms can be large for binding to enzymes and other proteins.
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Metadata
- Authors
- Jencks, W. P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1981-07
- Volume
- 78
- Issue
- 7
- Pages
- 4046-4050
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2007272508
- Cited by
- 912
- References
- 0
- FWCI
- 5.98
- Type
- journal article
- Language
- en
- Open access
- green
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- Jencks, W. P. (1981). On the attribution and additivity of binding energies. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.78.7.4046
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