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The structure of protein-protein recognition sites.
Open accessAbstract
The ability of certain proteins to form specific stable complexes is fundamental to biological existence. The structures of some 15 protease-inhibitor complexes (l-19) and 4 anti-body-protein antigen complexes (20-26) have been determined by x-ray crystallography, and we review the informa-tion that they provide on the structural basis of protein- protein recognition, We describe first the general features of the recognition sites. We then discuss whether recognition sites are regions of high mobility, the nature of the conformational changes that occur on the association of proteins, and the implications of these structural results for the kinetics and thermodynamics of association. view is largely confirmed structures
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Cited by
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Scheffzek, K., Ahmadian, M. R., Kabsch, W., Wiesmüller, L., Lautwein, A., Schmitz, F., & Wittinghofer, A. (1997) · Science · doi:10.1126/science.277.5324.333 · Cited by 1,543
Principles of docking: An overview of search algorithms and a guide to scoring functions
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Metadata
- Authors
- Janin, J., & Chothia, C.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1990-09
- Volume
- 265
- Issue
- 27
- Pages
- 16027-16030
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1526151739
- Cited by
- 819
- References
- 0
- FWCI
- 11.75
- Type
- journal article
- Language
- en
- Open access
- hybrid
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