The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Evidence against extrapancreatic insulin synthesis.
Open accessAbstract
Labeled and unlabeled insulin in acid/ethanol tissue extracts can be concentrated up to 100-fold by using a hydrophobic adsorption technique. After adsorption to and elution from an octadecylsilyl silica column, insulin is recovered in yields greater than 75%. By using this method of concentration, insulin in brain tissues of three of four fed rats and one rabbit was found to be less than 20% of plasma concentration. The kidney is the only extrapancreatic organ in which insulin is observed to be markedly above plasma levels. Porcine-insulin-like material was not detectable in guinea pig tissues (less than 0.02 ng/g). It is concluded that insulin is not synthesized in brain or other extrapancreatic tissues and that other mammalian insulins are not found in guinea pig tissues.
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Insulin concentration in the brain is less than that in the blood.
“Insulin concentration in the brain is less than that in the blood [37].”
From A mathematical model of brain glucose homeostasis (2009) · cites this paper as [37]
Citations
Cites
Immunochemical evidence of cholecystokinin-like peptides in brain
Dockray, G. J. (1976) · Nature · doi:10.1038/264568a0 · Cited by 688
Identification of insulin in rat brain.
Havránková, J., Schmechel, D. E., Roth, J., & Brownstein, M. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.11.5737 · Cited by 607
The Regional Distribution of Somatostatin in the Rat Brain
Brownstein, M. J., Arimura, A., SATO, H., Schally, A. V., & Kizer, J. S. (1975) · Endocrinology · doi:10.1210/endo-96-6-1456 · Cited by 594
Bryant, M. G., Bloom, S. R., Polar, J. M., et al. (1976) · The Lancet · doi:10.1016/s0140-6736(76)91863-8 · Cited by 494
Isolation, structure and biological activity of two cholecystokinin octapeptides from sheep brain
Dockray, G. J., GREGORY, R. A., Jb, H., Ji, H., & Mj, R. (1978) · Nature · doi:10.1038/274711a0 · Cited by 434
Havránková, J., Roth, J., & Brownstein, M. (1979) · Journal of Clinical Investigation · doi:10.1172/jci109504 · Cited by 325
Roith, D. L., Shiloach, J., Roth, J., & Lesniak, M. A. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.10.6184 · Cited by 279
Ectopic ACTH Production in Carcinoma of the Lung
GEWIRTZ, G. P., & Yalow, R. S. (1974) · Journal of Clinical Investigation · doi:10.1172/jci107639 · Cited by 271
Self-citationCholecystokinin and its COOH-terminal octapeptide in the pig brain.
Muller, J. E., Straus, E. W., & Yalow, R. S. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.7.3035 · Cited by 258
Self-citationBennett, H. P. J., Hudson, A. M., McMartin, C., et al. (1977) · Biochemical Journal · doi:10.1042/bj1680009 · Cited by 177
Insulin is ubiquitous in extrapancreatic tissues of rats and humans.
Rosenzweig, J. L., Havránková, J., Lesniak, M. A., Brownstein, M., & Roth, J. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.1.572 · Cited by 140
Insulin in Insects and Annelids
LeRoith, D., Lesniak, M. A., & Roth, J. (1981) · Diabetes · doi:10.2337/diab.30.1.70 · Cited by 107
Extrahypophysial distribution of corticotropin as a function of brain size.
Moldow, R. L., & Yalow, R. S. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.2.994 · Cited by 68
Self-citationInsulin Recoverable from Tissues
Eng, J., & Yalow, R. S. (1980) · Diabetes · doi:10.2337/diab.29.2.105 · Cited by 61
Self-citationExtrahypophysial distribution of thyrotropin as a function of brain size
Moldow, R. L., & Yalow, R. S. (1978) · Life Sciences · doi:10.1016/0024-3205(78)90604-5 · Cited by 30
Self-citationAlkaline extraction of cholecystokinin-immunoreactivity from rat brain
Ryder, S. W., Eng, J., Straus, E. W., et al. (1980) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(80)91289-9 · Cited by 17
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A mathematical model of brain glucose homeostasis
Gaohua, L., & Kimura, H. (2009) · Theoretical Biology and Medical Modelling · doi:10.1186/1742-4682-6-26 · Cited by 29
Metadata
- Authors
- Eng, J., & Yalow, R. S.
- ORCID
- Eng, J
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1981-07
- Volume
- 78
- Issue
- 7
- Pages
- 4576-4578
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC319835
- OpenAlex
- W2002983278
- Cited by
- 66
- References
- 16
- Citations by year
- 2019: 1 · 2018: 1 · 2016: 1 · 2012: 1
- FWCI
- 17.77
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- insulin, brain insulin, hydrophobic adsorption, guinea pig tissues, rats, rabbits
- MeSH terms
- Animals, Brain, Guinea Pigs, Insulin, Islets of Langerhans, Kidney, Liver, Rabbits, Silicon Dioxide, Rats
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