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Proteolytic processing of poliovirus polypeptides: antibodies to polypeptide P3-7c inhibit cleavage at glutamine-glycine pairs.
Open accessAbstract
Proteolytic processing of poliovirus polypeptides was examined by the addition of antibodies directed against the viral proteins P3-7c and P2-X to a cell-free translation extract prepared from infected HeLa cells. Antisera to P3-7c specifically inhibited in vitro processing at Gln-Gly pairs. Partial amino acid sequence analysis revealed a second Tyr-Gly pair that is utilized in protein processing. Neither Tyr-Gly cleavage is affected by antibody to P3-7c. Anti-P3-7c antibodies react not only with P3-7c but also with P3-6a and P3-2, two viral polypeptides NH2-coterminal with P3-7c. Preimmune and anti-P2-X antibodies had no effect on the processing of poliovirus proteins in vitro. We conclude that the activity responsible for processing poliovirus polypeptides at Gln-Gly pairs resides in the primary structure of P3-7c (or P3-2 and P3-6a) and not in P2-X.
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Citations
Cited by
Primary structural comparison of RNA-dependent polymerases from plant, animal and bacterial viruses
Kamer, G., & Argos, P. (1984) · Nucleic Acids Research · doi:10.1093/nar/12.18.7269 · Cited by 832
Ryan, M. D., King, A. M. Q., & Thomas, G. P. (1991) · Journal of General Virology · doi:10.1099/0022-1317-72-11-2727 · Cited by 477
Poliovirus proteinase 2A induces cleavage of eucaryotic initiation factor 4F polypeptide p220
Kräusslich, H. G., Nicklin, M. J., Toyoda, H., Etchison, D., & Wimmer, E. (1987) · Journal of Virology · doi:10.1128/jvi.61.9.2711-2718.1987 · Cited by 320
Self-citationGenomic structure of tbe large RNA segment of infectious bursal disease virus
Hudson, P. J., McKern, N. M., Power, B. E., & Azad, A. A. (1986) · Nucleic Acids Research · doi:10.1093/nar/14.12.5001 · Cited by 296
Cap-Binding Proteins of Eukaryotic Messenger RNA: Functions in Initiation and Control of Translation
Sonenberg, N. (1988) · Progress in Nucleic Acid Research and Molecular Biology · doi:10.1016/s0079-6603(08)60614-5 · Cited by 259
Metadata
- Authors
- Hanecak, R., Semler, B. L., Anderson, C. W., & Wimmer, E.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1982-07
- Volume
- 79
- Issue
- 13
- Pages
- 3973-3977
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2093399363
- Cited by
- 251
- References
- 0
- FWCI
- 14.14
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Proteolytic processing of poliovirus polypeptides: antibodies to polypeptide P3-7c inhibit cleavage at glutamine-glycine pairs. https://app.cochat.ai/papers/10.1073/pnas.79.13.3973
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- Hanecak, R., Semler, B. L., Anderson, C. W., & Wimmer, E. (1982). Proteolytic processing of poliovirus polypeptides: antibodies to polypeptide P3-7c inhibit cleavage at glutamine-glycine pairs. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.79.13.3973
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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