The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Complete nucleotide sequence of the attenuated poliovirus Sabin 1 strain genome.
Open accessAbstract
The complete nucleotide sequence of the genome of the type 1 poliovirus vaccine strain (LSc,2ab) was determined by using molecular cloning and rapid sequence analysis techniques. The restriction fragments of double-stranded cDNA synthesized from the vaccine strain RNA were inserted into the adequate sites of cloning vector pBR322. Sequence analysis of the cloned DNAs revealed that the virion RNA molecule was 7,441 nucleotides long and polyadenylylated at the 3' terminus. When the nucleotide sequence was compared with that of the genome of the virulent parental strain (Mahoney), 57 base substitutions were observed to be scattered all over the genome. Of these, 21 resulted in amino acid changes in a number of viral proteins. A cluster of amino acid changes is located in the viral coat proteins, especially in the NH2-terminal half of the viral capsid protein VP1. These results may imply that the mutations in the VP1 coding region contribute to attenuation.
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Cites
Intratypic Serodifferentiation of Poliomyelitis Virus Strains by Strain-Specific Antisera
van Weze, A. L., & Hazendonk, A. G. (1979) · Intervirology · doi:10.1159/000149005 · Cited by 106
Cited by
VACCINE-DERIVED POLIOVIRUSES AND THE ENDGAME STRATEGY FOR GLOBAL POLIO ERADICATION
Kew, O. M., Sutter, R. W., de Gourville, E. M., Dowdle, W. R., & Pallansch, M. A. (2005) · Annual Review of Microbiology · doi:10.1146/annurev.micro.58.030603.123625 · Cited by 703
Influences of mRNA secondary structure on initiation by eukaryotic ribosomes.
Kozak, M. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.9.2850 · Cited by 687
Wimmer, E., Hellen, C. U. T., & Cao, X. (1993) · Annual Review of Genetics · doi:10.1146/annurev.ge.27.120193.002033 · Cited by 554
Evans, D. M. A., Dunn, G., Minor, P. D., Schild, G. C., Cann, A. J., Stanway, G., Almond, J. W., Currey, K., & Maizel, J. V. (1985) · Nature · doi:10.1038/314548a0 · Cited by 440
Malim, M. H., Tiley, L. S., McCarn, D. F., Rusche, J. R., Hauber, J., & Cullen, B. R. (1990) · Cell · doi:10.1016/0092-8674(90)90670-a · Cited by 430
Metadata
- Authors
- Nomoto, A., Omata, T., Toyoda, H., Kuge, S., Horie, H., Kataoka, Y., Genba, Y., Nakano, Y., & Imura, N.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1982-10
- Volume
- 79
- Issue
- 19
- Pages
- 5793-5797
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1991624039
- Cited by
- 308
- References
- 1
- FWCI
- 16.90
- Type
- journal article
- Language
- en
- Open access
- green
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- Nomoto, A., Omata, T., Toyoda, H., Kuge, S., Horie, H., Kataoka, Y., Genba, Y., Nakano, Y., & Imura, N. (1982). Complete nucleotide sequence of the attenuated poliovirus Sabin 1 strain genome. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.79.19.5793
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