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Polymerization of the ninth component of complement (C9): formation of poly(C9) with a tubular ultrastructure resembling the membrane attack complex of complement.
Open accessAbstract
The ninth component of complement (C9) has a marked propensity to polymerize. C9 polymers [poly(C9)] formed spontaneously in Veronal-buffered saline upon incubation of purified C9 for 64 hr at 37 degrees C or within 2 hr at 46--56 degrees C. Poly(C9) formed at 37 degrees C was visualized by electron microscopy as a tubular structure with an internal diameter of 110 A and a length of 160 A. Its ultrastructure suggested a dodecameric composition and resembled that of the membrane attack complex of complement. The wider end of the tubular structure was formed by an approximately 30-A-thick torus with inner and outer diameters of 110 A and 220 A, respectively. Because the dimensions of C9 within poly(C9) were 160 x 55 A (maximal) and 20 A (minimal) and because monomeric C9 has dimensions of approximately 80 x 55 A, it is proposed that monomeric C9 unfolds during polymerization into tubules. Polymerization also occurred upon treatment of C9 for 1 hr at 37 degrees C with 0.6 M guanidine . HCl, 0.1 M octyl glucoside, or 1.5% sodium deoxycholate. Guanidine . HCl-induced C9 polymers consisted of elongated highly curved strands 55--80 A wide, suggesting that these polymers were formed by globular C9 that had not unfolded.
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Cited by
MOLLNES, T. E., LEA, T., FRØLAND, S. S., & HARBOE, M. (1985) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.1985.tb01871.x · Cited by 346
Young, J. D.-E., Cohn, Z. A., & Podack, E. R. (1986) · Science · doi:10.1126/science.2425429 · Cited by 273
Self-citationTerminal complexes of the complement system: New structural insights and their relevance to function
Morgan, B. P., Walters, D., Serna, M., & Bubeck, D. (2016) · Immunological Reviews · doi:10.1111/imr.12461 · Cited by 58
Retinal pigment epithelial cells mitigate the effects of complement attack by endocytosis of C5b-9
Georgiannakis, A., Burgoyne, T., Lueck, K., Futter, C., Greenwood, J., & Moss, S. E. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1500937 · Cited by 41
Breaching the Bacterial Envelope: The Pivotal Role of Perforin-2 (MPEG1) Within Phagocytes
Merselis, L. C., Rivas, Z. P., & Munson, G. P. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.597951 · Cited by 18
Metadata
- Authors
- Podack, E. R., & Tschopp, J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1982-01
- Volume
- 79
- Issue
- 2
- Pages
- 574-578
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2038153474
- Cited by
- 166
- References
- 0
- FWCI
- 8.24
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Polymerization of the ninth component of complement (C9): formation of poly(C9) with a tubular ultrastructure resembling the membrane attack complex of complement. https://app.cochat.ai/papers/10.1073/pnas.79.2.574
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- Podack, E. R., & Tschopp, J. (1982). Polymerization of the ninth component of complement (C9): formation of poly(C9) with a tubular ultrastructure resembling the membrane attack complex of complement. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.79.2.574
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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