The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Quantification of the Terminal Complement Complex in Human Plasma by an Enzyme‐Linked Immunosorbent Assay Based on Monoclonal Antibodies against a Neoantigen of the Complex
Abstract
The fluid‐phase terminal complement complex (TCC), consisting of the components C5b, C6, C7, C8, C9, and the S‐protein, has recently been detected in normal human plasma by using antibodies against native terminal complement components. Increased amounts of TCC were then found in several patients with in vivo activation of complement. We now describe a sensitive, specific, and reliable enzyme‐linked immunosorbent assay for quantification of the TCC, based on monoclonal antibodies against a neoantigen of the complex. The results indicate that the TCC is present in normal human plasma and in increased amounts in patients with complement activation in vivo, thus confirming previously obtained results. The assay is easy to perform and can be used for examination of large numbers of plasma samples.
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Citations
Cites
Use of staphylococcal protein A as an immunological reagent
Goding, J. W. (1978) · Journal of Immunological Methods · doi:10.1016/0022-1759(78)90259-4 · Cited by 941
Peroxidase labelled antibody and Fab conjugates with enhanced intracellular penetration
Avrameas, S., & Ternynck, T. (1971) · Immunochemistry · doi:10.1016/0019-2791(71)90395-8 · Cited by 862
MOLLNES, T. E., LEA, T., HARBOE, M., & TSCHOPP, J. (1985) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.1985.tb01870.x · Cited by 201
Self-citationTschopp, J., Müller-Eberhard, H. J., & Podack, E. R. (1982) · Nature · doi:10.1038/298534a0 · Cited by 183
Isolation of human S-protein, an inhibitor of the membrane attack complex of complement.
Podack, E. R., & Muller-Eberhard, H. J. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)83603-7 · Cited by 179
The membrane attack mechanism of complement. Isolation and subunit composition of the C5b-9 complex.
Kolb, W. P., & Muller-Eberhard, H. J. (1975) · The Journal of experimental medicine · doi:10.1084/jem.141.4.724 · Cited by 171
Podack, E. R., & Tschopp, J. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.2.574 · Cited by 164
Biesecker, G., Podack, E. R., Halverson, C., et al. (1979) · The Journal of Experimental Medicine · doi:10.1084/jem.149.2.448 · Cited by 99
Podack, E. R., & Tschopp, J. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)33414-8 · Cited by 82
Mollnes, T. E., Lea, T., & Harboe, M. (1984) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.1984.tb00989.x · Cited by 49
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Cited by
HARBOE, M., ULVUND, G., VIEN, L., FUNG, M., & MOLLNES, T. E. (2004) · Clinical and Experimental Immunology · doi:10.1111/j.1365-2249.2004.02627.x · Cited by 319
Self-citationHøgåsen, K., Mollnes, T. E., & Harboe, M. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)50058-2 · Cited by 73
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Metadata
- Authors
- MOLLNES, T. E., LEA, T., FRØLAND, S. S., & HARBOE, M.
- Venue
- Scandinavian Journal of Immunology
- Publisher
- Wiley
- Published
- 1985-08
- Volume
- 22
- Issue
- 2
- Pages
- 197-202
- ISSN
- 0300-9475 (ISSN-L)
- 1365-3083
- OpenAlex
- W2157217694
- Cited by
- 346
- References
- 10
- FWCI
- 4.04
- Type
- journal article
- Language
- en
- Open access
- closed
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- MOLLNES, T. E., LEA, T., FRØLAND, S. S., & HARBOE, M. (1985). Quantification of the Terminal Complement Complex in Human Plasma by an Enzyme‐Linked Immunosorbent Assay Based on Monoclonal Antibodies against a Neoantigen of the Complex. Scandinavian Journal of Immunology. https://doi.org/10.1111/j.1365-3083.1985.tb01871.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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