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Three distinct antigens associated with human T-lymphocyte-mediated cytolysis: LFA-1, LFA-2, and LFA-3.
Open accessAbstract
Monoclonal antibodies were prepared to anti-HLA-DR cytolytic T lymphocytes (CTLs) and screened for inhibition of CTL-mediated killing. Binding of monoclonal antibodies to four types of molecules, LFA-1, LFA-2, LFA-3, and HLA-DR, inhibited killing, suggesting that these molecules participate in the CTL-target cell interaction. The antigens were characterized by immunoprecipitation, crosslinking, NaDodSO4/polyacrylamide gel electrophoresis, and immunofluorescence flow cytometry. The LFA-1 antigen contains alpha and beta polypeptide chains of Mr 177,000 and 95,000 that are noncovalently associated in an alpha 1 beta 1 structure. It is present on both B and T lymphocytes and marks subpopulations that differ in quantitative expression. Human LFA-1 appears to be the homologue of mouse LFA-1. Human LFA-2 is of Mr 49,000 with a minor component of Mr 36,000. It is expressed on CTL lines but not on a B-cell line and in peripheral blood preferentially on T lymphocytes. Human LFA-3 is of Mr 60,000 and is expressed on both B and T lymphocytes.
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Citations
Cited by
T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1
Dustin, M. L., & Springer, T. A. (1989) · Nature · doi:10.1038/341619a0 · Cited by 1,538
Self-citationSanchez-Madrid, F., Nagy, J. A., Robbins, E., Simon, P., & Springer, T. A. (1983) · The Journal of experimental medicine · doi:10.1084/jem.158.6.1785 · Cited by 873
Self-citationA cell adhesion molecule, ICAM-1, is the major surface receptor for rhinoviruses
Staunton, D. E., Merluzzi, V. J., Rothlein, R., Barton, R., Marlin, S. D., & Springer, T. A. (1989) · Cell · doi:10.1016/0092-8674(89)90689-2 · Cited by 821
Self-citationDiamond, M. S., Garcia-Aguilar, J., Bickford, J. K., Corbi, A. L., & Springer, T. A. (1993) · The Journal of cell biology · doi:10.1083/jcb.120.4.1031 · Cited by 533
Self-citationDustin, M. L. (2014) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-14-0161 · Cited by 502
Metadata
- Authors
- Sanchez-Madrid, F., Krensky, A. M., Ware, C. F., Robbins, E., Strominger, J. L., Burakoff, S. J., & Springer, T. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1982-12
- Volume
- 79
- Issue
- 23
- Pages
- 7489-7493
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2140799426
- Cited by
- 718
- References
- 0
- FWCI
- 9.12
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Three distinct antigens associated with human T-lymphocyte-mediated cytolysis: LFA-1, LFA-2, and LFA-3. https://app.cochat.ai/papers/10.1073/pnas.79.23.7489
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- Sanchez-Madrid, F., Krensky, A. M., Ware, C. F., Robbins, E., Strominger, J. L., Burakoff, S. J., & Springer, T. A. (1982). Three distinct antigens associated with human T-lymphocyte-mediated cytolysis: LFA-1, LFA-2, and LFA-3. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.79.23.7489
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