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Quantitative model for gene regulation by lambda phage repressor.
Open accessAbstract
A statistical thermodynamic model has been developed to account for the cooperative interactions of the bacteriophage lambda repressor with the lambda right operator. The model incorporates a general theory for quantitatively interpreting cooperative site-specific equilibrium binding data. Values for all interaction parameters of the model have been evaluated at 37 degrees C, 0.2 M KCl, from results of DNase protection experiments in vitro [A. D. Johnson, B. J. Meyer, & M. Ptashne, Proc. Natl. Acad. Sci. USA (1979) 76, 5061-5065]. With these values, the model predicts repression curves at the divergent promoters PR and PRM that control transcription of genes coding for the regulatory proteins cro and repressor, respectively. At physiological repressor concentrations, repression at PR is predicted to be nearly complete whereas PRM is predicted to remain highly active. The results demonstrate the importance of cooperative interactions between repressor dimers bound to the adjacent operator sites OR1 and OR2 in maintaining a stable lysogenic state and in allowing efficient switchover to the lytic state during induction.
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“BAF inhibition did not affect the binding of rTetR alone (Fig. S3K), suggesting that BAF is specifically recruited by VP4821”
From Single-molecule states link transcription factor binding to gene expression (2024) · cites this paper as [21]
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“Because VP48 is known to directly interact with chromatin-remodeling cofactors21–23”
From Single-molecule states link transcription factor binding to gene expression (2024) · cites this paper as [21]
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Metadata
- Authors
- Ackers, G. K., Johnson, A. D., & Shea, M. A.
- Affiliations
- Harvard University (US)
- ORCID
- Shea, M A
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1982-02
- Volume
- 79
- Issue
- 4
- Pages
- 1129-1133
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC345914
- OpenAlex
- W2087234479
- Cited by
- 590
- References
- 25
- Citations by year
- 2026: 9 · 2025: 13 · 2024: 17 · 2023: 9 · 2022: 14 · 2021: 19 · 2020: 22 · 2019: 22 · 2018: 22 · 2017: 15 · 2016: 26 · 2015: 17 · 2014: 22 · 2013: 32 · 2012: 26
- FWCI
- 2.05
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation
- National Institutes of Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- cooperative DNA binding, statistical thermodynamic model, site-specific DNA binding, divergent promoters, lysogeny, gene expression regulation
- MeSH terms
- DNA-Binding Proteins, Gene Expression Regulation, Genes, Viral, Lysogeny, Mathematics, Models, Genetic, Operon, Bacteriophage lambda, Repressor Proteins, Transcription Factors, Viral Proteins, Virus Activation, Viral Regulatory and Accessory Proteins
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