Cited by 590Bacterial Genetics and BiotechnologyGene Regulatory Network AnalysisGenomics and Chromatin Dynamics

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Quantitative model for gene regulation by lambda phage repressor.

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Ackers, G K, Johnson, A D, Shea, M A·1982·Proceedings of the National Academy of Sciences

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Abstract

A statistical thermodynamic model has been developed to account for the cooperative interactions of the bacteriophage lambda repressor with the lambda right operator. The model incorporates a general theory for quantitatively interpreting cooperative site-specific equilibrium binding data. Values for all interaction parameters of the model have been evaluated at 37 degrees C, 0.2 M KCl, from results of DNase protection experiments in vitro [A. D. Johnson, B. J. Meyer, & M. Ptashne, Proc. Natl. Acad. Sci. USA (1979) 76, 5061-5065]. With these values, the model predicts repression curves at the divergent promoters PR and PRM that control transcription of genes coding for the regulatory proteins cro and repressor, respectively. At physiological repressor concentrations, repression at PR is predicted to be nearly complete whereas PRM is predicted to remain highly active. The results demonstrate the importance of cooperative interactions between repressor dimers bound to the adjacent operator sites OR1 and OR2 in maintaining a stable lysogenic state and in allowing efficient switchover to the lytic state during induction.

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Authors: Ackers, G. K., Johnson, A. D., & Shea, M. A.
Affiliations: Harvard University (US)
ORCID: Shea, M A
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 1982-02
Volume: 79
Issue: 4
Pages: 1129-1133
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.79.4.1129
PMC: PMC345914
OpenAlex: W2087234479
Cited by: 590
References: 25
Citations by year: 2026: 9 · 2025: 13 · 2024: 17 · 2023: 9 · 2022: 14 · 2021: 19 · 2020: 22 · 2019: 22 · 2018: 22 · 2017: 15 · 2016: 26 · 2015: 17 · 2014: 22 · 2013: 32 · 2012: 26
FWCI: 2.05
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Science Foundation
National Institutes of Health
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords: cooperative DNA binding, statistical thermodynamic model, site-specific DNA binding, divergent promoters, lysogeny, gene expression regulation
MeSH terms: DNA-Binding Proteins, Gene Expression Regulation, Genes, Viral, Lysogeny, Mathematics, Models, Genetic, Operon, Bacteriophage lambda, Repressor Proteins, Transcription Factors, Viral Proteins, Virus Activation, Viral Regulatory and Accessory Proteins

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Quantitative model for gene regulation by lambda phage repressor.

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