The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Phorbol diester receptor copurifies with protein kinase C.
Open accessAbstract
The phorbol diester receptor present in the particulate fraction of rat brain was solubilized by divalent ion chelation in the absence of detergents. The soluble receptor was partially purified by (NH4)2SO4 precipitation, DEAE-cellulose, and gel filtration chromatography. The purified receptor required exogenous phospholipid for activity and displayed a Kd of 7 nM for [3H]phorbol 12, 13-dibutyrate. Biologically active phorbol analogs inhibited binding, whereas inactive analogs did not. The Ca2+-dependent, phospholipid-sensitive protein kinase C copurified with the phorbol receptor. Purified protein kinase C was activated directly by phorbol 12-myristate 13-acetate in the presence of phospholipid.
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Citations
Cites
Castagna, M., Takai, Y., Kaibuchi, K., Sano, K., Kikkawa, U., & Nishizuka, Y. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)34459-4 · Cited by 4,725
Cited by
Protein kinase C as a possible receptor protein of tumor‐promoting phorbol esters
Kikkawa, U., Takai, Y., Tanaka, Y., Miyake, R., & Nishizuka, Y. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)44245-1 · Cited by 881
The Complete Primary Structure of Protein Kinase C—the Major Phorbol Ester Receptor
Parker, P. J., Coussens, L., Totty, N., Rhee, L., Young, S., Chen, E., Stabel, S., Waterfield, M. D., & Ullrich, A. (1986) · Science · doi:10.1126/science.3755547 · Cited by 854
Stocco, D. M., Wang, X., Jo, Y., & Manna, P. R. (2005) · Molecular Endocrinology · doi:10.1210/me.2004-0532 · Cited by 538
Wolf, M., LeVine, H., May, W. S., Cuatrecasas, P., & Sahyoun, N. (1985) · Nature · doi:10.1038/317546a0 · Cited by 441
Ballester, R., & Rosen, O. M. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)95721-2 · Cited by 379
Metadata
- Authors
- Niedel, J. E., Kuhn, L. J., & Vandenbark, G. R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1983-01
- Volume
- 80
- Issue
- 1
- Pages
- 36-40
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1970441944
- Cited by
- 1,169
- References
- 1
- FWCI
- 61.94
- Type
- journal article
- Language
- en
- Open access
- green
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- Niedel, J. E., Kuhn, L. J., & Vandenbark, G. R. (1983). Phorbol diester receptor copurifies with protein kinase C. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.80.1.36
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
