Cited by 538Adrenal Hormones and DisordersEstrogen and related hormone effectsSteroid Chemistry and Biochemistry

Multiple signaling pathways regulating steroidogenesis and steroidogenic acute regulatory protein expression: more complicated than we thought

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Stocco, Douglas M., Wang, XingJia, Jo, Youngah, Manna, Pulak R.·2005·Molecular Endocrinology

Abstract

Steroid hormone biosynthesis in steroidogenic cells is regulated through trophic hormone activation of protein kinase A (PKA) signaling pathways. However, many examples of the regulation of steroid synthesis via pathways other than the PKA pathway have been documented. In some cases these pathways act independently of PKA activation whereas in other cases, they act synergistically with it. The current understanding of additional signaling pathways and factors, such as the protein kinase C pathway, arachidonic acid metabolites, growth factors, chloride ion, the calcium messenger system, and others capable of regulating/modulating steroid hormone biosynthesis, and in many cases steroidogenic acute regulatory protein expression, are discussed in this review.

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Crossref · 10.1210/me.2004-0532

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  • ACTH rapidly stimulates StAR gene transcription and phosphorylation of Ser195 in extant StAR to increase the flow of cholesterol from the OMM to the IMM, where it becomes substrate for P450scc.

    “Third, ACTH rapidly stimulates StAR gene transcription (58) and phosphorylation of Ser195 in extant StAR (59) to increase the flow of cholesterol from the OMM to the IMM, where it becomes substrate for the first and rate-limiting enzyme, P450scc.”

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Authors
Stocco, D. M., Wang, X., Jo, Y., & Manna, P. R.
Affiliations
Texas Tech University (US)
Corresponding author
Stocco, Douglas M.
Venue
Molecular Endocrinology
Published
2005-11
Volume
19
Issue
11
Pages
2647-2659
ISSN
  • 0888-8809 (ISSN-L)
  • 1944-9917
OpenAlex
W2134876608
Cited by
538
References
131
Citations by year
2026: 6 · 2025: 24 · 2024: 16 · 2023: 17 · 2022: 24 · 2021: 20 · 2020: 24 · 2019: 26 · 2018: 24 · 2017: 24 · 2016: 24 · 2015: 36 · 2014: 34 · 2013: 27 · 2012: 41
FWCI
3.19
Type
journal article
Language
en
Open access
Locations
  • Molecular Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Welch Foundation
  • Texas Tech University
  • National Institutes of Health (1r03hd039308-01, HD17481)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD17481, HD-39308)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Steroid Chemistry and Biochemistry
Keywords
steroidogenesis, steroidogenic acute regulatory protein, protein kinase A signaling, protein kinase C pathway, arachidonic acid metabolites, growth factors, chloride, calcium signaling, trophic hormones
MeSH terms
Steroidogenic Acute Regulatory Protein, Cyclic AMP, Animals, Humans, Phosphoproteins, Protein Kinase C, Steroids, Signal Transduction, Arachidonic Acid, Mice, Rats

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