Multiple signaling pathways regulating steroidogenesis and steroidogenic acute regulatory protein expression: more complicated than we thought
Open accessAbstract
Steroid hormone biosynthesis in steroidogenic cells is regulated through trophic hormone activation of protein kinase A (PKA) signaling pathways. However, many examples of the regulation of steroid synthesis via pathways other than the PKA pathway have been documented. In some cases these pathways act independently of PKA activation whereas in other cases, they act synergistically with it. The current understanding of additional signaling pathways and factors, such as the protein kinase C pathway, arachidonic acid metabolites, growth factors, chloride ion, the calcium messenger system, and others capable of regulating/modulating steroid hormone biosynthesis, and in many cases steroidogenic acute regulatory protein expression, are discussed in this review.
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ACTH rapidly stimulates StAR gene transcription and phosphorylation of Ser195 in extant StAR to increase the flow of cholesterol from the OMM to the IMM, where it becomes substrate for P450scc.
“Third, ACTH rapidly stimulates StAR gene transcription (58) and phosphorylation of Ser195 in extant StAR (59) to increase the flow of cholesterol from the OMM to the IMM, where it becomes substrate for the first and rate-limiting enzyme, P450scc.”
From The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its Disorders (2011) · cites this paper as [58]
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The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its Disorders
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- Authors
- Stocco, D. M., Wang, X., Jo, Y., & Manna, P. R.
- Affiliations
- Texas Tech University (US)
- Corresponding author
- Stocco, Douglas M.
- Venue
- Molecular Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2005-11
- Volume
- 19
- Issue
- 11
- Pages
- 2647-2659
- ISSN
- 0888-8809 (ISSN-L)
- 1944-9917
- OpenAlex
- W2134876608
- Semantic Scholar
- d7b19a6e91347bf7f019f129e3a810d2556930cf
- Cited by
- 538
- References
- 131
- Citations by year
- 2026: 6 · 2025: 24 · 2024: 16 · 2023: 17 · 2022: 24 · 2021: 20 · 2020: 24 · 2019: 26 · 2018: 24 · 2017: 24 · 2016: 24 · 2015: 36 · 2014: 34 · 2013: 27 · 2012: 41
- FWCI
- 3.19
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Molecular Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Welch Foundation
- Texas Tech University
- National Institutes of Health (1r03hd039308-01, HD17481)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD17481, HD-39308)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Steroid Chemistry and Biochemistry
- Keywords
- steroidogenesis, steroidogenic acute regulatory protein, protein kinase A signaling, protein kinase C pathway, arachidonic acid metabolites, growth factors, chloride, calcium signaling, trophic hormones
- MeSH terms
- Steroidogenic Acute Regulatory Protein, Cyclic AMP, Animals, Humans, Phosphoproteins, Protein Kinase C, Steroids, Signal Transduction, Arachidonic Acid, Mice, Rats
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