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Macrophage activation: priming activity from a T-cell hybridoma is attributable to interferon-gamma.
Open accessAbstract
Antiviral and macrophage-priming activities in the supernatant medium of a subclone of a concanavalin A-stimulated mouse T-cell hybridoma were investigated. The two activities were associated with a molecular weight of approximately 50,000 and could not be separated by various approaches. Both activities were eliminated by a highly specific neutralizing antibody against mouse interferon-gamma, but not by antibody against interferon-alpha and -beta. The ratio of priming to antiviral activity in the hybridoma culture supernate was indistinguishable from the ratio obtained with mouse interferon-gamma prepared by recombinant DNA technology. It was concluded from these data that the priming activity in hybridoma culture supernates was attributable to interferon-gamma and that this mediator is one form of the lymphokine macrophage-activating factor. Interferon-gamma was greater than 800 times more efficient at priming mouse macrophages for tumor cell killing than was a mixture of interferon-alpha and -beta. This finding contributes to growing awareness that type II interferon may have greater immunoregulatory potential than type I interferons.
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Metadata
- Authors
- Pace, J. L., Russell, S. W., Schreiber, R. D., Altman, A., & Katz, D. H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1983-06
- Volume
- 80
- Issue
- 12
- Pages
- 3782-3786
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2035390621
- Cited by
- 184
- References
- 0
- FWCI
- 7.08
- Type
- journal article
- Language
- en
- Open access
- green
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- Pace, J. L., Russell, S. W., Schreiber, R. D., Altman, A., & Katz, D. H. (1983). Macrophage activation: priming activity from a T-cell hybridoma is attributable to interferon-gamma. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.80.12.3782
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