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Increase of proenkephalin mRNA and enkephalin content of rat striatum after daily injection of haloperidol for 2 to 3 weeks.
Open accessAbstract
Proenkephalin mRNA has been detected in striatum, hypothalamus, cortex, cerebellum, hippocampus, midbrain, and brain stem of rat by RNA ("Northern") blot analysis using a 918-base-pair DNA hybridization probe complementary to proenkephalin mRNA [Comb, M., Seeburg, P. H., Adelman, J., Eiden, L. & Herbert, E. (1982) Nature (London) 295, 663-666]. The size of the mRNA species in all brain regions is approximately 1,400 bases, and it was found to be comparable with that of bovine adrenal medulla and human pheochromocytoma. The data were quantified by densitometric scanning of the autoradiograms: the area under the peak is proportional to the amount of standard proenkephalin mRNA from bovine adrenal medulla. The relative content of proenkephalin mRNA in the various brain regions correlates generally with the content of [Met5]enkephalin-like immunoactivity of these regions. Rats receiving daily intraperitoneal injection of haloperidol (1 or 2 mg/kg) show a fourfold increase of proenkephalin mRNA content in striatum but not other brain regions. In agreement with previous reports, [Met5]enkephalin-like immunoactivity increased twofold in striatum.
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Citations
Cited by
The neostriatal mosaic: multiple levels of compartmental organization in the basal ganglia
Gerfen, C. R. (1992) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.15.030192.001441 · Cited by 1,004
Mesencephalic dopamine neurons regulate the expression of neuropeptide mRNAs in the rat forebrain.
Young, W. S., Bonner, T. I., & Brann, M. R. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.24.9827 · Cited by 743
Iadarola, M. J., Brady, L. S., Draisci, G., & Dubner, R. (1988) · Pain · doi:10.1016/0304-3959(88)90141-8 · Cited by 437
Sequence and expression of the rat prodynorphin gene.
Civelli, O., Douglass, J., Goldstein, A., & Herbert, E. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.12.4291 · Cited by 383
Iadarola, M. J., Douglass, J., Civelli, O., & Naranjo, J. R. (1988) · Brain Research · doi:10.1016/0006-8993(88)90078-9 · Cited by 268
Metadata
- Authors
- Tang, F., Costa, E., & Schwartz, J. P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1983-06
- Volume
- 80
- Issue
- 12
- Pages
- 3841-3844
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1986075380
- Cited by
- 283
- References
- 0
- FWCI
- 5.36
- Type
- journal article
- Language
- en
- Open access
- green
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- Tang, F., Costa, E., & Schwartz, J. P. (1983). Increase of proenkephalin mRNA and enkephalin content of rat striatum after daily injection of haloperidol for 2 to 3 weeks. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.80.12.3841
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