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Mesencephalic dopamine neurons regulate the expression of neuropeptide mRNAs in the rat forebrain.
Open accessAbstract
We used in situ hybridization histochemistry with synthetic oligodeoxyribonucleotide probes to identify cells that synthesize mRNAs encoding tyrosine hydroxylase in the mesencephalon and substance P, enkephalin, and dynorphin in the rat forebrain. Dopaminergic cells in the mesencephalon project to the forebrain and influence neuropeptide levels. We examined the effect of unilateral 6-hydroxydopamine lesions (which eliminated tyrosine hydroxylase mRNA-containing cells in the mesencephalon) on substance P, enkephalin, and dynorphin mRNA levels. Substance P mRNA levels were depressed, whereas enkephalin mRNA levels were elevated in consecutive sections from striatal areas in all animals. The effects of the lesions on dynorphin mRNA levels were less robust, and considerable variation between animals was observed. Changes were evident in the levels of message in individual cells but not in the numbers of labeled cells. These effects were not uniform throughout the dopamine-innervated areas, suggesting degrees of control not apparent with RNA blot-hybridization or dot-blot analyses.
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Cited by
Structure of a cannabinoid receptor and functional expression of the cloned cDNA
Matsuda, L. A., Lolait, S. J., Brownstein, M. J., Young, A. C., & Bonner, T. I. (1990) · Nature · doi:10.1038/346561a0 · Cited by 5,011
Self-citationD 1 and D 2 Dopamine Receptor-regulated Gene Expression of Striatonigral and Striatopallidal Neurons
Gerfen, C. R., Engber, T. M., Mahan, L. C., Susel, Z., Chase, T. N., Monsma, F. J., & Sibley, D. R. (1990) · Science · doi:10.1126/science.2147780 · Cited by 2,967
(1991) · Progress in Brain Research · doi:10.1016/s0079-6123(08)62678-3 · Cited by 1,961
Gerfen, C. R., & Scott Young, W. (1988) · Brain Research · doi:10.1016/0006-8993(88)91217-6 · Cited by 658
Lolait, S. J., O'Carroll, A.-M., McBride, O. W., Konig, M., Morel, A., & Brownstein, M. J. (1992) · Nature · doi:10.1038/357336a0 · Cited by 524
Metadata
- Authors
- Young, W. S., Bonner, T. I., & Brann, M. R.
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1986-12
- Volume
- 83
- Issue
- 24
- Pages
- 9827-9831
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2117593813
- Cited by
- 743
- References
- 0
- FWCI
- 11.04
- Type
- journal article
- Language
- en
- Open access
- green
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- Young, W. S., Bonner, T. I., & Brann, M. R. (1986). Mesencephalic dopamine neurons regulate the expression of neuropeptide mRNAs in the rat forebrain. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.83.24.9827
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