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Cited by 80Amino Acid Enzymes and MetabolismDigestive system and related healthClinical Nutrition and Gastroenterology

Regulation of proline and glucose transport in mouse intestine by dietary substrate levels.

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Karasov, W H, Pond, R S, Solberg, D H, Diamond, J M·1983·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.80.24.7674PMC PMC534403
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Abstract

Active uptake of D-glucose and L-proline at 50 mM was measured in everted intestinal sleeves of mice whose dietary carbohydrate and protein levels were being varied experimentally. Compared to a nearly carbohydrate-free meat diet, a 50% carbohydrate laboratory chow diet stimulated active glucose uptake in the proximal intestine without affecting proline uptake, passive glucose permeability, or several measures of mucosal mass. Switching from a low-protein high-carbohydrate to a high-protein no-carbohydrate diet reversibly stimulated proline uptake while inhibiting glucose uptake. For each solute and diet switch, the stimulation of transport was complete within 1 day, while the inhibition required several days. The results imply induction and repression of intestinal glucose and proline transport by dietary substrate levels. This mechanism, in conjunction with the normal gradient of nutrient concentrations along the intestine, is probably largely responsible for the gradient in nutrient transport along the intestine.

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  • A high-carbohydrate diet increases the number of sodium glucose co-transporter transporters in the intestine and their activity, allowing greater carbohydrate absorption and oxidation during exercise.

    “For example, a high-carbohydrate diet will increase the number of sodium glucose co-transporter transporters in the intestine as well as the activity of the transporters [75–78], allowing greater carbohydrate absorption and oxidation during exercise [74].”

    From Periodized Nutrition for Athletes (2017) · cites this paper as [78]

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Authors
Karasov, W. H., Pond, R. S., Solberg, D. H., & Diamond, J. M.
Affiliations
University of California, Los Angeles (US)
ORCID
Karasov, W H
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
1983-12
Volume
80
Issue
24
Pages
7674-7677
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.80.24.7674
PMC
PMC534403
OpenAlex
W1964516210
Cited by
80
References
21
Citations by year
2026: 1 · 2024: 1 · 2020: 1 · 2017: 2 · 2015: 4 · 2014: 1 · 2013: 2
FWCI
1.49
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Digestive system and related health
  • Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
Keywords
intestinal glucose transport, proline transport, dietary carbohydrates, dietary protein, proximal intestine, mouse intestine
MeSH terms
Animals, Biological Transport, Active, Dietary Carbohydrates, Glucose, Intestinal Absorption, Intestinal Mucosa, Jejunum, Kinetics, Male, Microvilli, Proline, Mice

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