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Cited by 229

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Multilocus genetic structure in natural populations of Escherichia coli.

Open access
Whittam, T S, Ochman, H, Selander, R K·1983·Proceedings of the National Academy of Sciences

Abstract

A survey of allozyme variation at 12 enzyme loci in 1,705 clones of the genetic species Escherichia coli (including four species of Shigella) from natural populations revealed 302 unique allele combinations (electrophoretic types). Single-locus diversity estimates fall within the range predicted by the neutral allele theory of molecular evolution, but the combination of alleles in electrophoretic types are highly nonrandom, as indicated by a test of association over all loci and by evidence of complex linkage disequilibria in several four-locus combinations. These linkage disequilibria reflect genetic differentiation of E. coli into three groups of strains. Because of restricted recombination, both the stochastic extinction of lines and selective differences between particular genetic combinations may have contributed to the evolution of subspecific structure in E. coli.

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Crossref · 10.1073/pnas.80.6.1751

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Metadata

Authors
Whittam, T. S., Ochman, H., & Selander, R. K.
Venue
Proceedings of the National Academy of Sciences
Published
1983-03
Volume
80
Issue
6
Pages
1751-1755
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W2070561312
Cited by
229
References
2
FWCI
4.80
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Multilocus genetic structure in natural populations of Escherichia coli. https://app.cochat.ai/papers/10.1073/pnas.80.6.1751
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Whittam, T. S., Ochman, H., & Selander, R. K. (1983). Multilocus genetic structure in natural populations of Escherichia coli. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.80.6.1751

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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