The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Dihydropyridine derivatives prolong the open state of Ca channels in cultured cardiac cells.
Open accessAbstract
The dihydropyridine derivatives CGP 28392 and BAY K 8644 exert a strong positive inotropic effect in mammalian cardiac muscle, presumably by increasing Ca influx during the action potential. Analysis of the drug effects at the level of single Ca channels by means of the patch-clamp method revealed complicated changes in the kinetics of channel gating. The prevailing effect is a prolongation of the mean open time of Ca channels. In addition, the intervals between channel openings can be slightly prolonged. Ensemble averages of single-channel traces showed a concentration-dependent increase in the mean current amplitude by the drugs. In contrast to beta-adrenoceptor agonists, the increase in Ca current by the dihydropyridine derivatives is not associated with an increase in the intracellular cyclic AMP level.
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Cites
Hamill, O. P., Marty, A., Neher, E., Sakmann, B., & Sigworth, F. J. (1981) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00656997 · Cited by 18,436
Down-Regulation of Na+/K+ATPase Activity by Human Parvovirus B19 Capsid Protein VP1
Almilaji, A., Szteyn, K., Fein, E., Pakladok, T., Munoz, C., Elvira, B., Towhid, S. T., Alesutan, I., Shumilina, E., Bock, C.-T., et al. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350083 · Cited by 8,675
Regulation of the Voltage Gated K+ Channel Kv1.3 by Recombinant Human Klotho Protein
Almilaji, A., Honisch, S., Liu, G., Elvira, B., Ajay, S. S., Hosseinzadeh, Z., Ahmed, M., Munoz, C., Sopjani, M., & Lang, F. (2014) · Kidney and Blood Pressure Research · doi:10.1159/000368472 · Cited by 5,592
Specific Pharmacology of Calcium in Myocardium, Cardiac Pacemakers, and Vascular Smooth Muscle
Fleckenstein, A. (1977) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.17.040177.001053 · Cited by 1,713
Calcium channel modulation by neurotransmitters, enzymes and drugs
Reuter, H. (1983) · Nature · doi:10.1038/301569a0 · Cited by 1,264
Self-citationNovel dihydropyridines with positive inotropic action through activation of Ca2+ channels
Schramm, M., Thomas, G., Towart, R., & Franckowiak, G. (1983) · Nature · doi:10.1038/303535a0 · Cited by 1,003
Lee, K. S., & Tsien, R. W. (1983) · Nature · doi:10.1038/302790a0 · Cited by 842
Osterrieder, W., Brum, G., Hescheler, J., Trautwein, W., Flockerzi, V., & Hofmann, F. (1982) · Nature · doi:10.1038/298576a0 · Cited by 418
β-Adrenergic modulation of calcium channels in frog ventricular heart cells
Bean, B. P., Nowycky, M. C., & Tsien, R. W. (1984) · Nature · doi:10.1038/307371a0 · Cited by 381
Properties of single calcium channels in cardiac cell culture
Reuter, H., Stevens, C. F., Tsien, R. W., & Yellen, G. (1982) · Nature · doi:10.1038/297501a0 · Cited by 340
Self-citation
Cited by
Dominant Role of N-Type Ca 2+ Channels in Evoked Release of Norepinephrine from Sympathetic Neurons
Hirning, L. D., Fox, A. P., McCleskey, E. W., Olivera, B. M., Thayer, S. A., Miller, R. J., & Tsien, R. W. (1988) · Science · doi:10.1126/science.2447647 · Cited by 853
Mason, R. P., Gonye, G. E., Chester, D. W., & Herbette, L. G. (1989) · Biophysical Journal · doi:10.1016/s0006-3495(89)82875-9 · Cited by 56
Metadata
- Authors
- Kokubun, S., & Reuter, H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1984-08
- Volume
- 81
- Issue
- 15
- Pages
- 4824-4827
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2035337103
- Cited by
- 320
- References
- 13
- FWCI
- 12.34
- Type
- journal article
- Language
- en
- Open access
- green
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- Kokubun, S., & Reuter, H. (1984). Dihydropyridine derivatives prolong the open state of Ca channels in cultured cardiac cells. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.81.15.4824
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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