The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Dominant Role of N-Type Ca 2+ Channels in Evoked Release of Norepinephrine from Sympathetic Neurons
Abstract
Multiple types of calcium channels have been found in neurons, but uncertainty remains about which ones are involved in stimulus-secretion coupling. Two types of calcium channels in rat sympathetic neurons were described, and their relative importance in controlling norepinephrine release was analyzed. N-type and L-type calcium channels differed in voltage dependence, unitary barium conductance, and pharmacology. Nitrendipine inhibited activity of L-type channels but not N-type channels. Potassium-evoked norepinephrine release was markedly reduced by cadmium and the conesnail peptide toxin ω- Conus geographus toxin VIA, agents that block both N- and L-type channels, but was little affected by nitrendipine at concentrations that strongly reduce calcium influx, as measured by fura-2. Thus N-type calcium channels play a dominant role in the depolarization-evoked release of norepinephrine.
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Cites
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Self-citationMultiple Calcium Channels and Neuronal Function
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Cited by
Multiple types of neuronal calcium channels and their selective modulation
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Self-citationSyntaxin: A Synaptic Protein Implicated in Docking of Synaptic Vesicles at Presynaptic Active Zones
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Self-citationkappa-Opioid receptor signaling and brain reward function
Bruijnzeel, A. W. (2009) · Brain Research Reviews · doi:10.1016/j.brainresrev.2009.09.008 · Cited by 214
Metadata
- Authors
- Hirning, L. D., Fox, A. P., McCleskey, E. W., Olivera, B. M., Thayer, S. A., Miller, R. J., & Tsien, R. W.
- Venue
- Science
- Published
- 1988-01
- Volume
- 239
- Issue
- 4835
- Pages
- 57-61
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2053559739
- Cited by
- 853
- References
- 32
- FWCI
- 31.13
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hirning, L. D., Fox, A. P., McCleskey, E. W., Olivera, B. M., Thayer, S. A., Miller, R. J., & Tsien, R. W. (1988). Dominant Role of N-Type Ca 2+ Channels in Evoked Release of Norepinephrine from Sympathetic Neurons. Science. https://doi.org/10.1126/science.2447647
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
