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A gene regulating the heat shock response in Escherichia coli also affects proteolysis.
Open accessAbstract
The htpR locus in Escherichia coli encodes a regulator of the heat shock response. Cells containing the htpR165 mutation are defective in the induction of synthesis of heat-shock proteins at high temperature. We show that these cells are also defective in degrading two proteins that are normally unstable in htpR+ cells. The proteolytic defect is manifest at both 30 degrees C and 42 degrees C. We used a marker rescue technique to map this defect to the htpR locus. Although both proteolytic substrates are partially stabilized in lon- strains, we argue that the defect in proteolysis exhibited by the htpR165 strain does not mimic the lon- state. The htpR165 strain synthesizes Lon at the normal rate at 30 degrees C and does not show the phenotypes of mucoidy and radiation sensitivity associated with lon- strains.
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Cited by
Rimm, D. L., Koslov, E. R., Kebriaei, P., Cianci, C. D., & Morrow, J. S. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.19.8813 · Cited by 735
Evolution of heat‐shock protein expression underlying adaptive responses to environmental stress
Chen, B., Feder, M. E., & Kang, L. (2018) · Molecular Ecology · doi:10.1111/mec.14769 · Cited by 267
Katayama, Y., Gottesman, S., Pumphrey, J., Rudikoff, S., Clark, W. P., & Maurizi, M. R. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)68168-2 · Cited by 253
EphA2 is an epithelial cell pattern recognition receptor for fungal β-glucans
Swidergall, M., Solis, N. V., Lionakis, M. S., & Filler, S. G. (2017) · Nature Microbiology · doi:10.1038/s41564-017-0059-5 · Cited by 167
Metadata
- Authors
- Baker, T. A., Grossman, A. D., & Gross, C. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1984-11
- Volume
- 81
- Issue
- 21
- Pages
- 6779-6783
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2000610610
- Cited by
- 172
- References
- 0
- FWCI
- 5.02
- Type
- journal article
- Language
- en
- Open access
- green
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- Baker, T. A., Grossman, A. D., & Gross, C. A. (1984). A gene regulating the heat shock response in Escherichia coli also affects proteolysis. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.81.21.6779
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