The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
pH-sensitive liposomes: acid-induced liposome fusion.
Open accessAbstract
Sonicated unilamellar liposomes containing phosphatidylethanolamine and palmitoylhomocysteine fuse rapidly when the medium pH is lowered from 7 to 5. Liposome fusion was demonstrated by (i) mixing of the liposomal lipids as shown by resonance energy transfer, (ii) gel filtration, and (iii) electron microscopy. The pH-sensitive fusion of liposomes was observed only when palmitoylhomocysteine (greater than or equal to 20 mol%) was present in the liposomes. The presence of phosphatidyl-ethanolamine in the liposomes greatly enhanced fusion whereas the presence of phosphatidylcholine inhibited fusion. During fusion of liposomes containing phosphatidylethanolamine and palmitoylhomocysteine (8:2, mol/mol), almost all of the encapsulated calcein was released. Inclusion of cholesterol (40 mol%) in the liposomes substantially decreased leakage without impairing fusion.
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Citations
Cites
Lipid polymorphism and the functional roles of lipids in biological membranes
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Use of resonance energy transfer to monitor membrane fusion
Struck, D. K., Hoekstra, D., & Pagano, R. E. (1981) · Biochemistry · doi:10.1021/bi00517a023 · Cited by 1,277
Rapid acidification of endocytic vesicles containing α2-macroglobulin
Tycko, B., & Maxfield, F. R. (1982) · Cell · doi:10.1016/0092-8674(82)90219-7 · Cited by 671
Cell fusion by Semliki Forest, influenza, and vesicular stomatitis viruses.
White, J., Matlin, K., & Helenius, A. (1981) · The Journal of cell biology · doi:10.1083/jcb.89.3.674 · Cited by 558
Serum-induced leakage of liposome contents
Allen, T. M., & Cleland, L. G. (1980) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(80)90118-2 · Cited by 468
p H-Sensitive Liposomes: Possible Clinical Implications
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Self-citationStraubinger, R. M., Hong, K., Friend, D. S., & Papahadjopoulos, D. (1983) · Cell · doi:10.1016/0092-8674(83)90291-x · Cited by 393
The Fusion of Biological Membranes
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pH-dependent fusion between the Semliki Forest virus membrane and liposomes.
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Cited by
Andresen, T. L., Jensen, S. S., & Jørgensen, K. (2005) · Progress in Lipid Research · doi:10.1016/j.plipres.2004.12.001 · Cited by 580
Schroeder, A., Kost, J., & Barenholz, Y. (2009) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2009.08.003 · Cited by 485
Biocompatibility of nanomaterials and their immunological properties
Kyriakides, T. R., Raj, A., Tseng, T. H., Xiao, H., Nguyen, R., Mohammed, F. S., Halder, S., Xu, M., Wu, M. J., Bao, S., et al. (2021) · Biomedical Materials · doi:10.1088/1748-605x/abe5fa · Cited by 389
Fusion of cationic liposomes with mammalian cells occurs after endocytosis
Wrobel, I., & Collins, D. (1995) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(95)80017-a · Cited by 339
Metadata
- Authors
- Connor, J., Yatvin, M. B., & Huang, L.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1984-03
- Volume
- 81
- Issue
- 6
- Pages
- 1715-1718
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2073734538
- Cited by
- 287
- References
- 13
- FWCI
- 4.30
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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