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p H-Sensitive Liposomes: Possible Clinical Implications
Abstract
When p H-sensitive molecules are incorporated into liposomes, drugs can be specifically released from these vesicles by a change of p H in the ambient serum. Liposomes containing the p H-sensitive lipid palmitoyl homocysteine (PHC) were constructed so that the greatest p H differential (6.0 to 7.4) of drug release was obtained near physiological temperature. Such liposomes could be useful clinically if they enable drugs to be targeted to areas of the body in which p H is less than physiological, such as primary tumors and metastases or sites of inflammation and infection.
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Citations
Cited by
Liposomal drug delivery systems: From concept to clinical applications
Allen, T. M., & Cullis, P. R. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.09.037 · Cited by 4,839
Impact of Nanotechnology on Drug Delivery
Farokhzad, O. C., & Langer, R. (2009) · ACS Nano · doi:10.1021/nn900002m · Cited by 3,348
Tenchov, R., Bird, R., Curtze, A. E., & Zhou, Q. (2021) · ACS Nano · doi:10.1021/acsnano.1c04996 · Cited by 2,221
Langer, R. (1990) · Science · doi:10.1126/science.2218494 · Cited by 1,778
New developments in liposomal drug delivery
Pattni, B. S., Chupin, V. V., & Torchilin, V. P. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00046 · Cited by 1,600
Metadata
- Authors
- Yatvin, M. B., Kreutz, W., Horwitz, B. A., & Shinitzky, M.
- Venue
- Science
- Published
- 1980-12-12
- Volume
- 210
- Issue
- 4475
- Pages
- 1253-1255
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1984447304
- Cited by
- 415
- References
- 0
- FWCI
- 5.02
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: p H-Sensitive Liposomes: Possible Clinical Implications. https://app.cochat.ai/papers/10.1126/science.7434025
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- Yatvin, M. B., Kreutz, W., Horwitz, B. A., & Shinitzky, M. (1980). p H-Sensitive Liposomes: Possible Clinical Implications. Science. https://doi.org/10.1126/science.7434025
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