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Ly-1 B cells: functionally distinct lymphocytes that secrete IgM autoantibodies.
Open accessAbstract
Studies presented here introduce another perspective on the mechanisms responsible for IgM autoantibody production. A unique subpopulation of B lymphocytes (Ly-1 B) that concomitantly expresses IgM, IgD, Ia, and Ly-1 membrane glycoproteins is present at higher frequencies in NZB and NZB-related mice. The Ly-1 B subpopulation in these autoimmune animals is responsible for the "spontaneous" IgM secretion demonstrated with cultured NZB spleen cells and contains the cells that secrete typical NZB IgM autoantibodies to single-stranded DNA and to thymocytes. In addition, the Ly-1 B population in normal mouse strains (and in NZB) contains virtually all of the spleen cells that secrete IgM autoantibodies reactive with bromelain-treated mouse erythrocytes. Since a different B-cell subpopulation (IgM+, IgD-, Ly-1) secretes most of the IgM antibodies produced in responses to exogenous antigens, we conclude that Ly-1 B cells constitute a functionally distinct B-cell population important in certain kinds of autoimmunity.
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Cited by
CXCL13 is required for B1 cell homing, natural antibody production, and body cavity immunity.
Ansel, K. M., Harris, R. B. S., & Cyster, J. G. (2002) · Immunity · doi:10.1016/s1074-7613(01)00257-6 · Cited by 449
Differential development of progenitor activity for three B-cell lineages.
Kantor, A. B., Stall, A. M., Adams, S., Herzenberg, L. A., & Herzenberg, L. A. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.8.3320 · Cited by 314
Self-citationFörster, I., & Rajewsky, K. (1987) · European Journal of Immunology · doi:10.1002/eji.1830170414 · Cited by 313
Hardy, R. R. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.5.2749 · Cited by 249
Self-citationKojima, H., Gu, H., Nomura, S., Caldwell, C. C., Kobata, T., Carmeliet, P., Semenza, G. L., & Sitkovsky, M. V. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.052706699 · Cited by 224
Metadata
- Authors
- Hayakawa, K., Hardy, R. R., Honda, M., Herzenberg, L. A., Steinberg, A. D., & Herzenberg, L. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1984-04
- Volume
- 81
- Issue
- 8
- Pages
- 2494-2498
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2016190951
- Cited by
- 637
- References
- 0
- FWCI
- 36.16
- Type
- journal article
- Language
- en
- Open access
- green
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- Hayakawa, K., Hardy, R. R., Honda, M., Herzenberg, L. A., Steinberg, A. D., & Herzenberg, L. A. (1984). Ly-1 B cells: functionally distinct lymphocytes that secrete IgM autoantibodies. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.81.8.2494
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