B-1 B Cell Development
Abstract
CD5+ B cells have attracted considerable interest because of their association with self-reactivity, autoimmunity, and leukemia. In mice, CD5+ B cells are readily generated from fetal/neonatal precursors, but inefficiently from precursors in adult. One model proposed to explain this difference is that their production occurs through a distinctive developmental process, termed B-1, that enriches pre-B cells with novel germline VDJs and that requires positive selection of newly formed B cells by self-Ag. In contrast, follicular B cells are generated throughout adult life in a developmental process termed B-2, selecting VDJs that pair well with surrogate L chain, and whose maturation appears relatively independent of antigenic selection. In the present study, I focus on processes that shape the repertoire of mouse CD5+ B cells, describing the differences between B-1 and B-2 development, and propose a model encompassing both in the generation of functional B cell subpopulations.
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B1 B cells are innate-like immune cells that play a pivotal role in early immune defense.
“B1 B cells are a subset of innate-like immune cells that play a pivotal role in early immune defense.”
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Hiéronimus, L., & Huaux, F. (2023) · Frontiers in Toxicology · doi:10.3389/ftox.2023.960861 · Cited by 8 · see citing works
“, via self-antigen recognition) on B-0 leads to the development of B-1 cells (Hardy, 2006; Ghosh et al., 2022).”
BackgroundIgM Antibodies Can Access Cryptic Antigens Denied to IgG: Hypothesis on Novel Binding Mechanism
Law, E., Leung, D., Tam, F., Cheung, K., Cheng, N. H.-Y., & Lim, P. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01820 · Cited by 8
Immunology: The expanding TH2 universe
Strober, W. (2010) · Nature · doi:10.1038/463434a · Cited by 8
Corfe, S. A., & Paige, C. (2009) · Springer eBooks · doi:10.1007/978-0-387-85816-6_8 · Cited by 8 · see citing works
Vlachonikola, E., Sofou, E., Chatzidimitriou, A., Stamatopoulos, K., & Agathangelidis, A. (2021) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2021.03.003 · Cited by 7 · see citing works
dos Santos, D. C., Lovero, K. L., Schmidt, C., Barros, A. C. M., Quintanilha, A. P., Barbosa, A. P., Pone, M., Pone, S., Araújo, J., Martins, C. D. P., et al. (2020) · Tuberculosis · doi:10.1016/j.tube.2020.101960 · Cited by 7
“This result is supported by previous research showing that levels of CD4 and CD8 cells do not interfere with the levels of anti-phospholipid IgM antibodies produced in HIV-infected individuals [18,19].”
ResultJones, M. A., DeWolf, S., Vacharathit, V., Yim, M., Spencer, S. R., & Bamezai, A. (2016) · PLoS ONE · doi:10.1371/journal.pone.0157271 · Cited by 6 · see citing works
“We examined the expression of B220 and CD5 proteins to enumerate the B-1 and B-2 cells from the retrieved peritoneal exudates (PEC) from the wild- type and Ly-6A/Sca-1 Knockout mice [35].”
MethodThe Role of Graft and Host Accommodation in a Hamster-to-Rat Cardiac Transplantation Model
Komori, K., Fuchimoto, Y., Morikawa, Y., Obara, H., Kawachi, S., Tanabe, M., Hoshino, K., Shimazu, M., Matsuzaki, Y., & Kitajima, M. (2008) · Transplantation · doi:10.1097/01.tp.0000296030.88283.92 · Cited by 5
A Chronological Journey of Breg Subsets: Implications in Health and Disease
Dar, H. Y., Rani, L., Sapra, L., Azam, Z., Shokeen, N., Bhardwaj, A., Mishra, G. C., & Srivastava, R. (2020) · Springer eBooks · doi:10.1007/978-981-15-3350-1_5 · Cited by 5 · see citing works
- Authors
- Hardy, R. R.
- Affiliations
- Fox Chase Cancer Center (US)
- Corresponding author
- Hardy, Richard R
- ORCID
- Hardy, Richard R
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-09-01
- Volume
- 177
- Issue
- 5
- Pages
- 2749-2754
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2129375889
- Cited by
- 249
- References
- 87
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 3 · 2023: 8 · 2022: 8 · 2021: 8 · 2020: 6 · 2019: 8 · 2018: 12 · 2017: 14 · 2016: 9 · 2015: 10 · 2014: 18 · 2013: 22 · 2012: 17
- FWCI
- 1.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (AI26782, R01AI040946, AI 40946)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Pathology and Forensic Medicine › Lymphoma Diagnosis and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- CD5+ B cells, pre-B cells, V(D)J recombination, positive selection, autoantigens, surrogate light chain, B cell receptor repertoire, autoimmunity, B-cell leukemia
- MeSH terms
- Animals, B-Lymphocytes, Cell Differentiation, Humans, Lymphocyte Activation, Models, Immunological, CD5 Antigens, Cell Lineage
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