The DOI matches its Crossref record.
Amino acid sequence of homologous rat atrial peptides: natriuretic activity of native and synthetic forms.
Open accessAbstract
A substance called atrial natriuretic factor (ANF), localized in secretory granules of atrial cardiocytes, was isolated as four homologous natriuretic peptides from homogenates of rat atria. The complete sequence of the longest form showed that it is composed of 33 amino acids. The three other shorter forms (2-33, 3-33, and 8-33) represent amino-terminally truncated versions of the 33 amino acid parent molecule as shown by analysis of sequence, amino acid composition, or both. The proposed primary structure agrees entirely with the amino acid composition and reveals no significant sequence homology with any known protein or segment of protein. The short form ANF-(8-33) was synthesized by a multi-fragment condensation approach and the synthetic product was shown to exhibit specific activity comparable to that of the natural ANF-(3-33).
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Atrial Natriuretic Peptide Elevation in Congestive Heart Failure in the Human
Burnett, J. C., Kao, P. C., Hu, D. C., Heser, D. W., Heublein, D., Granger, J. P., Opgenorth, T. J., & Reeder, G. S. (1986) · Science · doi:10.1126/science.2935937 · Cited by 891
Maack, T., Marion, D. N., Camargo, M. J. F., Kleinert, H. D., Laragh, J. H., Vaughan, E. D., & Atlas, S. A. (1984) · The American Journal of Medicine · doi:10.1016/0002-9343(84)90190-6 · Cited by 522
Cloning and sequence analysis of cDNA encoding a precursor for human atrial natriuretic poly peptide
Oikawa, S., Imai, M., Ueno, A., Tanaka, S., Noguchi, T., Nakazato, H., Kangawa, K., Fukuda, A., & Matsuo, H. (1984) · Nature · doi:10.1038/309724a0 · Cited by 317
Seidah, N. G., Abifadel, M., Prost, S., Boileau, C., & Prat, A. (2017) · Pharmacological Reviews · doi:10.1124/pr.116.012989 · Cited by 116
Self-citationEngler, D., Redei, E., & Kola, I. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.4.0376 · Cited by 79
Metadata
- Authors
- Seidah, N. G., Lazure, C., Chrétien, M., Thibault, G., Garcia, R., Cantin, M., Genest, J., Nutt, R. F., Brady, S. F., & Lyle, T. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1984-05
- Volume
- 81
- Issue
- 9
- Pages
- 2640-2644
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2102568784
- Cited by
- 210
- References
- 0
- FWCI
- 75.32
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Amino acid sequence of homologous rat atrial peptides: natriuretic activity of native and synthetic forms. https://app.cochat.ai/papers/10.1073/pnas.81.9.2640
- The paper
- Seidah, N. G., Lazure, C., Chrétien, M., Thibault, G., Garcia, R., Cantin, M., Genest, J., Nutt, R. F., Brady, S. F., & Lyle, T. A. (1984). Amino acid sequence of homologous rat atrial peptides: natriuretic activity of native and synthetic forms. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.81.9.2640
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
