The corticotropin–release inhibitory factor hypothesis: a review of the evidence for the existence of inhibitory as well as stimulatory hypophysiotropic regulation of adrenocorticotropin secretion and biosynthesis
Abstract
Introduction II.Hypothalamic Stimulation of ACTH Release and Biosynthesis A. Corticotropin-releasing factor (CRF) B. Arginine vasopressin (AVP) C. The hypothalamic CRF and AVP neurons and their connections D. Studies of the secretion of CRF and AVP into the hypophysial-portal circulation E. Studies of the neural regulation of CRF and AVP secretion and biosynthesis III.Hypothalamic Inhibition of ACTH Release and Biosynthesis A. Historic studies B. Effect of hypothalamo-pituitary disconnection in adult and fetal sheep C. Effects of the opiate alkaloids and opioid peptides on the HPA axis D. The role of the posterior pituitary in the regulation of corticotropic function E. Hypothalamic ACTH release-inhibitory activity F. Definition of corticotropin release inhibitory factor (CRIF) IV.CRIF: A Consideration of Possible Candidates A. Somatostatin (SST) B. Dopamine C. Atrial natriuretic peptide (ANP) D. Prepro-TRH-(178-199) E. Other substances V.
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Both in human and in rat, the CRH reaction pathway is considered to be dominant in pituitary-adrenal regulation.
“Namely, both in human (39, 43–47, 55) and in rat (26, 36–38, 40, 41), CRH reaction pathway is considered to be dominant in pituitary-adrenal regulation.”
From Influence of arginine vasopressin on the ultradian dynamics of Hypothalamic-Pituitary-Adrenal axis (2022) · cites this paper as [55]
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- Authors
- Engler, D., Redei, E., & Kola, I.
- Affiliations
- Monash Medical Centre (AU)
- Northwestern University (US)
- ORCID
- Redei, Eva
- Venue
- Endocrine Reviews
- Publisher
- The Endocrine Society
- Published
- 1999-08-01
- Volume
- 20
- Issue
- 4
- Pages
- 460-500
- ISSN
- 0163-769X (ISSN-L)
- 1945-7189
- OpenAlex
- W2076105668
- Cited by
- 79
- References
- 468
- Citations by year
- 2022: 3 · 2020: 2 · 2019: 4 · 2018: 1 · 2016: 4 · 2014: 1 · 2013: 2 · 2012: 3
- FWCI
- 0.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrine Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- ACTH secretion, hypothalamic regulation, vasopressin, hypothalamic-pituitary-adrenal axis, somatostatin, dopamine, atrial natriuretic peptide, thyrotropin-releasing hormone, neurohypophysis, opioid peptides
- MeSH terms
- Adrenocorticotropic Hormone, Animals, Haplorhini, Arginine Vasopressin, Corticotropin-Releasing Hormone, Dogs, Dopamine, Horses, Humans, Hypothalamo-Hypophyseal System, Atrial Natriuretic Factor, Peptide Fragments, Protein Precursors, Sheep, Somatostatin, Thyrotropin-Releasing Hormone, Rats
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