CoChat
Sign Up
Cited by 330Blood disorders and treatmentsinterferon and immune responsesHematological disorders and diagnostics

The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.

Interferon is a mediator of hematopoietic suppression in aplastic anemia in vitro and possibly in vivo

Open access
Zoumbos, N C, Gascon, P, Djeu, J Y, Young, N S·1985·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.82.1.188PMC PMC396997
Open this paper in CoChat — free account

Abstract

We have investigated interferon as a mediator of hematopoietic suppression in bone marrow failure. Interferon production by stimulated peripheral blood mononuclear cells from patients with aplastic anemia was significantly higher than that observed in controls; spontaneous interferon production by these cells was also high for more than half of aplastic anemia patients. Circulating interferon, not detectable in normal individuals, was detected in 10 of 24 patients. Interferon is a potent inhibitor of hematopoietic cell proliferation and, therefore, may be the mediator of suppression in many in vitro models employing patients' cells and sera. The possible pathogenic importance of interferon in aplastic anemia was suggested by an increase in hematopoietic colony formation in vitro after exposure of bone marrow cells to antiinterferon antisera (277 +/- 71% increase for patients compared to 1.6 +/- 1.6% for normal individuals). Interferon levels in the bone marrow sera of aplastic anemia patients were high (mean = 203 international units (IU)/ml, n = 8), even in comparison to circulating levels in the same patients. Normal bone marrow sera also contained measurable interferon but at lower levels (41 IU/ml, n = 16), indicating that interferon may be a normal bone marrow product. High concentration of bone marrow interferon, possibly due to abnormal immunologic activity or a reaction to virus infection of the bone marrow, may mediate hematopoietic suppression in aplastic anemia patients.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1073/pnas.82.1.188

Cites

35 of 35 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Show all 35 references

Cited by

Sorted by citations

Related

See all

Metadata

Authors
Zoumbos, N. C., Gascon, P., Djeu, J. Y., & Young, N. S.
ORCID
Young, N S
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
1985-01
Volume
82
Issue
1
Pages
188-192
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.82.1.188
PMC
PMC396997
OpenAlex
W2064632541
Cited by
330
References
35
Citations by year
2026: 4 · 2025: 3 · 2024: 4 · 2023: 5 · 2022: 6 · 2021: 9 · 2020: 5 · 2019: 5 · 2018: 10 · 2017: 7 · 2016: 2 · 2015: 6 · 2014: 4 · 2013: 7 · 2012: 6
FWCI
11.83
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Hematology › Blood disorders and treatments
  • Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
  • Health Sciences › Medicine › Hematology › Hematological disorders and diagnostics
Keywords
interferon, aplastic anemia, hematopoietic suppression, bone marrow failure, peripheral blood mononuclear cells, hematopoietic colony formation, immunological activity
MeSH terms
Anemia, Aplastic, Bone Marrow Cells, Hematopoiesis, Humans, Interferon-gamma, Isoantibodies, Monocytes

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review