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Differentiation-enhanced binding of the amino-terminal fragment of human urokinase plasminogen activator to a specific receptor on U937 monocytes.
Open accessAbstract
The purified amino-terminal fragment (ATF) of human urokinase plasminogen activator (residues 1-135), which is not required for activation of plasminogen, binds with high affinity to specific plasma membrane receptors on U937 monocytes. Intact urokinase efficiently competes for 125I-labeled ATF binding; 50% competition occurs with 1 nM urokinase. A large part of receptor-bound urokinase remains on the cell surface for at least 2 hr at 37 degrees C. Differentiation of U937 monocytes into macrophage-like cells specifically increases ATF binding 10- to 20-fold. These results suggest an important role for urokinase in monocyte/macrophage biology: the native enzyme binds to the cells with the amino-terminal domain; the catalytic, carboxyl-terminal domain remains exposed on the cell surface to stimulate localized proteolysis and facilitate cell migration.
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Citations
Cited by
Mahmood, N., Mihalcioiu, C., & Rabbani, S. A. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00024 · Cited by 478
Plasminogen Activation Initiated by Single-chain Urokinase-type Plasminogen Activator
Ellis, V, Scully, M. F., & Kakkar, V. V. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)94159-1 · Cited by 332
Pericyte Migration from the Vascular Wall in Response to Traumatic Brain Injury
Dore-Duffy, P., Owen, C., Balabanov, R., Murphy, S., Beaumont, T., & Rafols, J. A. (2000) · Microvascular Research · doi:10.1006/mvre.2000.2244 · Cited by 304
Behrendt, N., Rønne, E., Ploug, M., Petri, T., Løber, D., Nielsen, L. S., Schleuning, W. D., Blasi, F., Appella, E., & Danø, K. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)39348-2 · Cited by 274
Self-citationMetrangolo, V., Ploug, M., & Engelholm, L. H. (2021) · Cancers · doi:10.3390/cancers13215376 · Cited by 44
Metadata
- Authors
- Stoppelli, M. P., Corti, A., Soffientini, A., Cassani, G., Blasi, F., & Assoian, R. K.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1985-08
- Volume
- 82
- Issue
- 15
- Pages
- 4939-4943
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2115947409
- Cited by
- 443
- References
- 0
- FWCI
- 13.51
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Differentiation-enhanced binding of the amino-terminal fragment of human urokinase plasminogen activator to a specific receptor on U937 monocytes. https://app.cochat.ai/papers/10.1073/pnas.82.15.4939
- The paper
- Stoppelli, M. P., Corti, A., Soffientini, A., Cassani, G., Blasi, F., & Assoian, R. K. (1985). Differentiation-enhanced binding of the amino-terminal fragment of human urokinase plasminogen activator to a specific receptor on U937 monocytes. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.82.15.4939
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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