The DOI matches its Crossref record.
Actinomycin and DNA transcription.
Open accessAbstract
Recent advances in understanding how actinomycin binds to DNA have suggested its mechanism of action. Actinomycin binds to a premelted DNA conformation present within the transcriptional complex. This immobilizes the complex, interfering with the elongation of growing RNA chains. The model has a number of implications for understanding RNA synthesis.
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Citations
Cited by
A brief history of the antibiotic era: lessons learned and challenges for the future
Aminov, R. I. (2010) · Frontiers in Microbiology · doi:10.3389/fmicb.2010.00134 · Cited by 1,628
Li, W., Zhang, H., Assaraf, Y. G., Zhao, K., Xu, X., Xie, J., Yang, D.-H., & Chen, Z.-S. (2016) · Drug Resistance Updates · doi:10.1016/j.drup.2016.05.001 · Cited by 673
Sharova, L. V., Sharov, A. A., Nedorezov, T., Piao, Y., Shaik, N., & Ko, M. S. H. (2009) · DNA Research · doi:10.1093/dnares/dsn030 · Cited by 591
“The most widely used methods for high-throughput analysis of mRNA degradation is based on transcriptional inhibitors, for example by actinomycin D, which inhibits transcription via binding to single-strand DNA at the transcription initiation complex and preventing elongation by RNA polymerase II.(31) Multiple studies…”
MethodRNA-Mediated Feedback Control of Transcriptional Condensates
Henninger, J. E., Oksuz, O., Shrinivas, K., Sagi, I., LeRoy, G., Zheng, M. M., Andrews, J. O., Zamudio, A. V., Lazaris, C., Hannett, N. M., et al. (2021) · Cell · doi:10.1016/j.cell.2020.11.030 · Cited by 594
Inhibition of RNA polymerase II as a trigger for the p53 response
Ljungman, M., Zhang, F., Chen, F., Rainbow, A. J., & McKay, B. C. (1999) · Oncogene · doi:10.1038/sj.onc.1202356 · Cited by 288
Metadata
- Authors
- Sobell, H. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1985-08
- Volume
- 82
- Issue
- 16
- Pages
- 5328-5331
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1969528530
- Cited by
- 561
- References
- 0
- FWCI
- 1.90
- Type
- journal article
- Language
- en
- Open access
- green
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- Sobell, H. M. (1985). Actinomycin and DNA transcription. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.82.16.5328
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
