The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Apolipoprotein multigene family: tandem organization of human apolipoprotein AI, CIII, and AIV genes.
Open accessAbstract
The genes for two of the proteins of the plasma lipid transport system, apolipoprotein AI (apoAI) and CIII (apoCIII) are closely linked in the human genome. An approximately equal to 30-kilobase (kb) DNA segment containing these genes and their flanking sequences has been cloned and extensively characterized. Hybridization studies revealed that a DNA fragment located 12 kb 3' to the apoAI gene contains sequences homologous to a 1.8-kb mRNA transcript in human fetal intestine and adult liver but not in fetal liver, kidney, heart, brain, or muscle. This DNA fragment was used as a probe to isolate a clone from an adult human liver cDNA library. The nucleotide sequence of this clone is 74.8% homologous to the cDNA sequence of rat apolipoprotein AIV (apoAIV), another protein of the lipid transport system, and codes for a protein that is 58.6% identical to rat apoAIV. These results indicate that apoAI, apoCIII, and apoAIV genes are closely linked in the human genome and suggest that all three of them are derived from a common ancestral precursor.
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Cites
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Cited by
Hypertriglyceridemia as a Result of Human apo CII Gene Expression in Transgenic Mice
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Role of apoCs in lipoprotein metabolism: functional differences between apoC1, apoC2, and apoC3
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Apolipoprotein C-III: understanding an emerging cardiovascular risk factor
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Self-citationApolipoprotein C1: Its Pleiotropic Effects in Lipid Metabolism and Beyond
Fuior, E. V., & Gafencu, A. V. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20235939 · Cited by 186
Metadata
- Authors
- Karathanasis, S. K.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1985-10
- Volume
- 82
- Issue
- 19
- Pages
- 6374-6378
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2090454074
- Cited by
- 358
- References
- 30
- FWCI
- 30.76
- Type
- journal article
- Language
- en
- Open access
- green
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- Karathanasis, S. K. (1985). Apolipoprotein multigene family: tandem organization of human apolipoprotein AI, CIII, and AIV genes. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.82.19.6374
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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