The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Induction of the proto-oncogene fos by nerve growth factor.
Open accessAbstract
Nerve growth factor (NGF) causes the differentiation of PC12 cells to sympathetic neuron-like cells and also induces a rapid but transient expression of fos mRNA and protein. fos mRNA transcripts can be detected 5 min after the addition of NGF, are maximally abundant after 30 min, and then their levels decrease. fos protein synthesis parallels the expression of fos mRNA, and the induced fos proteins are located in the nucleus. cAMP, epidermal growth factor, the phorbol ester phorbol 12-myristate 13-acetate, and K+ depolarization also induce the fos gene. Growth of PC12 cells in the presence of dexamethasone, which induces differentiation into chromaffin-like cells, is not accompanied by fos expression. We propose that while fos gene induction is associated with the differentiation of PC12 cells to sympathetic nerve, its enhanced expression is primarily involved in the anabolic responses induced by NGF and many growth factors.
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Cites
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Cited by
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Metadata
- Authors
- Kruijer, W., Schubert, D., & Verma, I. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1985-11
- Volume
- 82
- Issue
- 21
- Pages
- 7330-7334
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2065538605
- Cited by
- 347
- References
- 46
- FWCI
- 11.87
- Type
- journal article
- Language
- en
- Open access
- green
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- Kruijer, W., Schubert, D., & Verma, I. M. (1985). Induction of the proto-oncogene fos by nerve growth factor. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.82.21.7330
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
