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Cited by 2,516HER2/EGFR in Cancer ResearchCancer-related Molecular PathwaysT-cell and Retrovirus Studies

Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences

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Downward, J., Yarden, Y., Mayes, E., Scrace, G., Totty, N., Stockwell, P., Ullrich, A., Schlessinger, J. +1 more·1984·Nature
DOI 10.1038/307521a0
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Abstract

Each of six peptides derived from the human epidermal growth factor (EGF) receptor very closely matches a part of the deduced sequence of the v-erb-B transforming protein of avian erythroblastosis virus (AEV). In all, the peptides contain 83 amino acid residues, 74 of which are shared with v-erb-B. The AEV progenitor may have acquired the cellular gene sequences of a truncated EGF receptor (or closely related protein) lacking the external EGF-binding domain but retaining the transmembrane domain and a domain involved in stimulating cell proliferation. Transformation of cells by AEV may result, in part, from the inappropriate acquisition of a truncated EGF receptor from the c-erb-B gene.

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  • The EGF receptor was originally identified as an oncogene because of its homology to v-ERBB, a retroviral protein that enables the avian erythroblastosis virus to transform chicken cells.

    “The EGF receptor was originally identified as an oncogene because of its homology to v-ERBB, a retroviral protein that enables the avian erythroblastosis virus to transform chicken cells (Downward et al., 1984).”

    From ERBB Receptors: From Oncogene Discovery to Basic Science to Mechanism-Based Cancer Therapeutics (2014) · cites this paper as Downward et al., 1984

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Research works printed but not linked: 22

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Authors
Downward, J., Yarden, Y., Mayes, E., Scrace, G., Totty, N., Stockwell, P., Ullrich, A., Schlessinger, J., & Waterfield, M. D.
Affiliations
  • Weizmann Institute of Science (IL)
  • University of Otago (NZ)
  • Genentech (US)
ORCID
Venue
Nature
Publisher
Springer Science and Business Media LLC
Published
1984-02
Volume
307
Issue
5951
Pages
521-527
ISSN
  • 0028-0836 (ISSN-L)
  • 1476-4687
DOI
10.1038/307521a0
OpenAlex
W2016568386
Cited by
2,516
References
67
Citations by year
2026: 18 · 2025: 9 · 2024: 7 · 2023: 10 · 2022: 14 · 2021: 13 · 2020: 13 · 2019: 16 · 2018: 13 · 2017: 19 · 2016: 16 · 2015: 23 · 2014: 22 · 2013: 21 · 2012: 18
FWCI
172.65
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (tdm)
Locations
  • Nature (publishedVersion)
  • PubMed (publishedVersion)
Funders
Israel Cancer Research Fund
Topics
  • Health Sciences › Medicine › Oncology › HER2/EGFR in Cancer Research
  • Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
Keywords
epidermal growth factor receptor, avian erythroblastosis virus, receptor tyrosine kinase, viral oncogenesis, receptor truncation, cell proliferation, sequence homology
MeSH terms
Amino Acid Sequence, Cell Cycle, Cell Transformation, Viral, Epidermal Growth Factor, Humans, Oncogenes, Receptors, Cell Surface, ErbB Receptors

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