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Human group-specific component (Gc) is a member of the albumin family.
Abstract
The group-specific component (Gc) is the major vitamin D-binding protein in plasma. The gene encoding Gc is linked, on human chromosome 4, to the albumin and alpha-fetoprotein genes. These two genes previously were shown to have evolved from a smaller ancestral gene by intragenic triplication. Recombinant plasmids containing human cDNA encoding Gc have been isolated by screening an adult human liver library with a mixed oligonucleotide probe. Characterization of Gc cDNA has provided the complete amino acid sequence of the protein and revealed strong sequence homology with albumin and alpha-fetoprotein. Of particular interest is a conserved pattern of disulfide bridges that form the triple-domain structures in albumin, alpha-fetoprotein, and Gc. Gc cDNA was used as a probe in Southern blot analysis of somatic-cell hybrids to confirm that the Gc locus is on chromosome 4.
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“The VDBP is located on the human chromosome 4 (Bollen et al. 2023; Yang et al. 1985) and is responsible for the binding and transport of all vitamin D metabolites.”
From Vitamin D status and its determinants in German elite athletes (2025) · cites this paper as Yang et al. 1985
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Henderson, C. M., Lutsey, P. L., Misialek, J. R., Laha, T. J., Selvin, E., Eckfeldt, J. H., & Hoofnagle, A. N. (2016) · Clinical Chemistry · doi:10.1373/clinchem.2015.244541 · Cited by 140
Braun, A., Bichlmaier, R., & Cleve, H. (1992) · Human Genetics · doi:10.1007/bf00194311 · Cited by 137
Vitamin D status and its determinants in German elite athletes
Hacker, S., Lenz, C., Reichert, L., Ringseis, R., Zentgraf, K., & Krüger, K. (2025) · European Journal of Applied Physiology · doi:10.1007/s00421-024-05699-6 · Cited by 9
Metadata
- Authors
- Yang, F., Brune, J. L., Naylor, S. L., Cupples, R. L., Naberhaus, K. H., & Bowman, B. H.
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1985-12
- Volume
- 82
- Issue
- 23
- Pages
- 7994-7998
- ISSN
- 0027-8424
- 1091-6490
- Cited by
- 95
- References
- 0
- Language
- en
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- CoChat. (2026). Citation check: Human group-specific component (Gc) is a member of the albumin family. https://app.cochat.ai/papers/10.1073/pnas.82.23.7994
- The paper
- Yang, F., Brune, J. L., Naylor, S. L., Cupples, R. L., Naberhaus, K. H., & Bowman, B. H. (1985). Human group-specific component (Gc) is a member of the albumin family. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.82.23.7994
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
